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DARS

GENERAL INFORMATION

Gene name

 DARS

Gene description

 Aspartyl-tRNA synthetase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA020451 , HPA029804 , HPA029805
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DARS

Synonyms

Description

 Aspartyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Chromosome

 2

Cytoband

 q21.3

Chromosome location (bp)

 135906677 - 135986100

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115866 (version 83.38)

Entrez gene

 1615

UniProt

 P14868 (UniProt - Evidence at protein level)

neXtProt

 NX_P14868

Antibodypedia

 DARS antibodies

PROTEIN BROWSER
DARS-001
DARS-002
DARS-003
DARS-004
DARS-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DARS-001
ENSP00000264161
ENST00000264161
P14868 [Direct mapping]
Aspartate--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0004046 [aminoacylase activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004815 [aspartate-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006422 [aspartyl-tRNA aminoacylation]
GO:0006461 [protein complex assembly]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
Show all
 501 aa
57.1 kDa 		No 0
DARS-002
ENSP00000397616
ENST00000456565
C9J7S3 [Direct mapping]
Aspartate--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006418 [tRNA aminoacylation for protein translation]
Show all
 176 aa
20 kDa 		No 0
DARS-003
ENSP00000388801
ENST00000449218
C9JQM9 [Direct mapping]
Aspartate--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006418 [tRNA aminoacylation for protein translation]
Show all
 135 aa
15.3 kDa 		No 0
DARS-004
ENSP00000389867
ENST00000441323
C9JLC1 [Direct mapping]
Aspartate--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006418 [tRNA aminoacylation for protein translation]
Show all
 182 aa
20.6 kDa 		No 0
DARS-009
ENSP00000387508
ENST00000422708
H7BZ35 [Direct mapping]
Aspartate--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006418 [tRNA aminoacylation for protein translation]
Show all
 188 aa
21.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.