Expression of EDEM3 in cancer - Summary

CANCER ATLAS

Gene description

ER degradation enhancer, mannosidase alpha-like 3

Protein class

Enzymes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA025754	HPA025755

GENE INFORMATION
Gene name	EDEM3 (HGNC Symbol)
Synonyms	C1orf22
Description	ER degradation enhancer, mannosidase alpha-like 3 (HGNC Symbol)
Entrez gene summary	Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008]
Chromosome	1
Cytoband	q25.3
Chromosome location (bp)	184690231 - 184754913
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116406 (version 83.38)
Entrez gene	80267
UniProt	Q9BZQ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZQ6
Antibodypedia	EDEM3 antibodies

PROTEIN BROWSER

EDEM3-001	EDEM3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EDEM3-001 ENSP00000318147 ENST00000318130	Q9BZQ6 [Direct mapping] ER degradation-enhancing alpha-mannosidase-like protein 3 A0A024R931 [Target identity:100%; Query identity:100%] alpha-1,2-Mannosidase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004569 [glycoprotein endo-alpha-1,2-mannosidase activity] GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006457 [protein folding] GO:0006491 [N-glycan processing] GO:0006516 [glycoprotein catabolic process] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044322 [endoplasmic reticulum quality control compartment] GO:0097466 [glycoprotein ERAD pathway] GO:1904382 [mannose trimming involved in glycoprotein ERAD pathway] Show all	932 aa 104.7 kDa	Yes	0
EDEM3-201 ENSP00000356482 ENST00000367512	Q9BZQ6 [Direct mapping] ER degradation-enhancing alpha-mannosidase-like protein 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006457 [protein folding] GO:0006491 [N-glycan processing] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044322 [endoplasmic reticulum quality control compartment] GO:0097466 [glycoprotein ERAD pathway] GO:1904382 [mannose trimming involved in glycoprotein ERAD pathway] Show all	905 aa 102 kDa	No	0