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EDEM3

GENERAL INFORMATION

Gene name

 EDEM3

Gene description

 ER degradation enhancer, mannosidase alpha-like 3

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA025754 , HPA025755
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin05101520253035TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin024681012RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina020406080100Tags Per Million

GENE INFORMATION

Gene name

 EDEM3 (HGNC Symbol)

Synonyms

 C1orf22

Description

 ER degradation enhancer, mannosidase alpha-like 3 (HGNC Symbol)

Entrez gene summary

 Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008]

Chromosome

 1

Cytoband

 q25.3

Chromosome location (bp)

 184690231 - 184754913

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116406 (version 83.38)

Entrez gene

 80267

UniProt

 Q9BZQ6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BZQ6

Antibodypedia

 EDEM3 antibodies

PROTEIN BROWSER
EDEM3-001
EDEM3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EDEM3-001
ENSP00000318147
ENST00000318130
Q9BZQ6 [Direct mapping]
ER degradation-enhancing alpha-mannosidase-like protein 3
A0A024R931 [Target identity:100%; Query identity:100%]
alpha-1,2-Mannosidase
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004569 [glycoprotein endo-alpha-1,2-mannosidase activity]
GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity]
GO:0005509 [calcium ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006457 [protein folding]
GO:0006491 [N-glycan processing]
GO:0006516 [glycoprotein catabolic process]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044322 [endoplasmic reticulum quality control compartment]
GO:0097466 [glycoprotein ERAD pathway]
GO:1904382 [mannose trimming involved in glycoprotein ERAD pathway]
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 932 aa
104.7 kDa 		Yes 0
EDEM3-201
ENSP00000356482
ENST00000367512
Q9BZQ6 [Direct mapping]
ER degradation-enhancing alpha-mannosidase-like protein 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity]
GO:0005509 [calcium ion binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006457 [protein folding]
GO:0006491 [N-glycan processing]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044322 [endoplasmic reticulum quality control compartment]
GO:0097466 [glycoprotein ERAD pathway]
GO:1904382 [mannose trimming involved in glycoprotein ERAD pathway]
Show all
 905 aa
102 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.