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Most of the cancer tissues showed weak to moderate cytoplasmic positivity. A few pancreatic and endometrial cancers were strongly stained. Several gliomas, thyroid ad renal cancers were negative.
A majority of cancer tissues displayed moderate to strong cytoplasmic and occasional nucleolar positivity. The breast, renal, testicular, lung and prostate cancers were weakly stained or negative.
A majority of cancer cells displayed weak to moderate cytoplasmic immunoreactivity. Strong staining was observed in a few endometrial cancers. Most renal, lung and testicular cancers were negative.
GENE INFORMATION
Gene name
PLA2G4A (HGNC Symbol)
Synonyms
cPLA2-alpha, PLA2G4
Description
Phospholipase A2, group IVA (cytosolic, calcium-dependent) (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)