Fields »
ABOUT
HELP
BLOG
PLA2G4A

GENERAL INFORMATION

Gene name

 PLA2G4A

Gene description

 Phospholipase A2, group IVA (cytosolic, calcium-dependent)

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (parathyroid gland)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression, most abundant in parathyroid gland and seminal vesicle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA050062 , HPA054206 , CAB010050
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Rectum
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Parathyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
N/ACerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin050100150200TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin05101520RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina020406080100120140Tags Per Million

GENE INFORMATION

Gene name

 PLA2G4A (HGNC Symbol)

Synonyms

 cPLA2-alpha, PLA2G4

Description

 Phospholipase A2, group IVA (cytosolic, calcium-dependent) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Chromosome

 1

Cytoband

 q31.1

Chromosome location (bp)

 186828953 - 186988981

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116711 (version 83.38)

Entrez gene

 5321

UniProt

 P47712 (UniProt - Evidence at protein level)

neXtProt

 NX_P47712

Antibodypedia

 PLA2G4A antibodies

PROTEIN BROWSER
PLA2G4A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLA2G4A-001
ENSP00000356436
ENST00000367466
P47712 [Direct mapping]
Cytosolic phospholipase A2 Phospholipase A2 Lysophospholipase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001542 [ovulation from ovarian follicle]
GO:0001554 [luteolysis]
GO:0004620 [phospholipase activity]
GO:0004622 [lysophospholipase activity]
GO:0004623 [phospholipase A2 activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005743 [mitochondrial inner membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0006663 [platelet activating factor biosynthetic process]
GO:0006690 [icosanoid metabolic process]
GO:0007568 [aging]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0009395 [phospholipid catabolic process]
GO:0009408 [response to heat]
GO:0009725 [response to hormone]
GO:0010033 [response to organic substance]
GO:0010226 [response to lithium ion]
GO:0010243 [response to organonitrogen compound]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019369 [arachidonic acid metabolic process]
GO:0030168 [platelet activation]
GO:0030501 [positive regulation of bone mineralization]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031394 [positive regulation of prostaglandin biosynthetic process]
GO:0031622 [positive regulation of fever generation]
GO:0032496 [response to lipopolysaccharide]
GO:0033280 [response to vitamin D]
GO:0035035 [histone acetyltransferase binding]
GO:0035965 [cardiolipin acyl-chain remodeling]
GO:0036148 [phosphatidylglycerol acyl-chain remodeling]
GO:0036149 [phosphatidylinositol acyl-chain remodeling]
GO:0036150 [phosphatidylserine acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0042127 [regulation of cell proliferation]
GO:0042542 [response to hydrogen peroxide]
GO:0042588 [zymogen granule]
GO:0043065 [positive regulation of apoptotic process]
GO:0043129 [surfactant homeostasis]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0046456 [icosanoid biosynthetic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0046697 [decidualization]
GO:0047498 [calcium-dependent phospholipase A2 activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050482 [arachidonic acid secretion]
GO:0050729 [positive regulation of inflammatory response]
GO:0051384 [response to glucocorticoid]
GO:0051592 [response to calcium ion]
GO:0051597 [response to methylmercury]
GO:0071236 [cellular response to antibiotic]
Show all
 749 aa
85.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.