Expression of SDHB in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Protein class

Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA002868	CAB009822	CAB068233	CAB068234	CAB068235

GENE INFORMATION
Gene name	SDHB (HGNC Symbol)
Synonyms	SDH, SDH1
Description	Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (HGNC Symbol)
Entrez gene summary	Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.13
Chromosome location (bp)	17018722 - 17054170
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117118 (version 83.38)
Entrez gene	6390
UniProt	P21912 (UniProt - Evidence at protein level)
neXtProt	NX_P21912
Antibodypedia	SDHB antibodies

PROTEIN BROWSER

SDHB-001	SDHB-006	SDHB-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SDHB-001 ENSP00000364649 ENST00000375499	P21912 [Direct mapping] Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Citric acid cycle related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)] GO:0006099 [tricarboxylic acid cycle] GO:0006105 [succinate metabolic process] GO:0008177 [succinate dehydrogenase (ubiquinone) activity] GO:0009055 [electron carrier activity] GO:0009060 [aerobic respiration] GO:0016491 [oxidoreductase activity] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045273 [respiratory chain complex II] GO:0046872 [metal ion binding] GO:0048039 [ubiquinone binding] GO:0051536 [iron-sulfur cluster binding] GO:0051537 [2 iron, 2 sulfur cluster binding] GO:0051538 [3 iron, 4 sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	280 aa 31.6 kDa	Yes	0
SDHB-006 ENSP00000481376 ENST00000463045	A0A087WXX8 [Direct mapping] Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0006099 [tricarboxylic acid cycle] GO:0009055 [electron carrier activity] GO:0016491 [oxidoreductase activity] GO:0051536 [iron-sulfur cluster binding] GO:0051537 [2 iron, 2 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	123 aa 14.1 kDa	No	0
SDHB-008 ENSP00000480482 ENST00000491274	A0A087WWT1 [Direct mapping] Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0006099 [tricarboxylic acid cycle] GO:0008177 [succinate dehydrogenase (ubiquinone) activity] GO:0009055 [electron carrier activity] GO:0016491 [oxidoreductase activity] GO:0046872 [metal ion binding] GO:0051536 [iron-sulfur cluster binding] GO:0051537 [2 iron, 2 sulfur cluster binding] GO:0051538 [3 iron, 4 sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	200 aa 22.7 kDa	No	0