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SDHB

GENERAL INFORMATION

Gene name

 SDHB

Gene description

 Succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Protein class

 Cancer-related genes
Citric acid cycle related proteins
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in all cell types.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 5 antibodies.
HPA002868 , CAB009822 , CAB068233 , CAB068234 , CAB068235
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SDHB (HGNC Symbol)

Synonyms

 SDH, SDH1

Description

 Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (HGNC Symbol)

Entrez gene summary

 Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 17018722 - 17054170

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117118 (version 83.38)

Entrez gene

 6390

UniProt

 P21912 (UniProt - Evidence at protein level)

neXtProt

 NX_P21912

Antibodypedia

 SDHB antibodies

PROTEIN BROWSER
SDHB-001
SDHB-006
SDHB-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SDHB-001
ENSP00000364649
ENST00000375499
P21912 [Direct mapping]
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)]
GO:0006099 [tricarboxylic acid cycle]
GO:0006105 [succinate metabolic process]
GO:0008177 [succinate dehydrogenase (ubiquinone) activity]
GO:0009055 [electron carrier activity]
GO:0009060 [aerobic respiration]
GO:0016491 [oxidoreductase activity]
GO:0022904 [respiratory electron transport chain]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045273 [respiratory chain complex II]
GO:0046872 [metal ion binding]
GO:0048039 [ubiquinone binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051537 [2 iron, 2 sulfur cluster binding]
GO:0051538 [3 iron, 4 sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 280 aa
31.6 kDa 		Yes 0
SDHB-006
ENSP00000481376
ENST00000463045
A0A087WXX8 [Direct mapping]
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006099 [tricarboxylic acid cycle]
GO:0009055 [electron carrier activity]
GO:0016491 [oxidoreductase activity]
GO:0051536 [iron-sulfur cluster binding]
GO:0051537 [2 iron, 2 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
Show all
 123 aa
14.1 kDa 		No 0
SDHB-008
ENSP00000480482
ENST00000491274
A0A087WWT1 [Direct mapping]
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005743 [mitochondrial inner membrane]
GO:0006099 [tricarboxylic acid cycle]
GO:0008177 [succinate dehydrogenase (ubiquinone) activity]
GO:0009055 [electron carrier activity]
GO:0016491 [oxidoreductase activity]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051537 [2 iron, 2 sulfur cluster binding]
GO:0051538 [3 iron, 4 sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
Show all
 200 aa
22.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.