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PRDX1

GENERAL INFORMATION

Gene name

 PRDX1

Gene description

 Peroxiredoxin 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA007730 , CAB004682
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PRDX1 (HGNC Symbol)

Synonyms

 NKEFA, PAGA

Description

 Peroxiredoxin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

Chromosome

 1

Cytoband

 p34.1

Chromosome location (bp)

 45511036 - 45523047

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117450 (version 83.38)

Entrez gene

 5052

UniProt

 Q06830 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06830

Antibodypedia

 PRDX1 antibodies

PROTEIN BROWSER
PRDX1-001
PRDX1-002
PRDX1-003
PRDX1-004
PRDX1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRDX1-001
ENSP00000361152
ENST00000319248
Q06830 [Direct mapping]
Peroxiredoxin-1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001501 [skeletal system development]
GO:0001895 [retina homeostasis]
GO:0004601 [peroxidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008379 [thioredoxin peroxidase activity]
GO:0010467 [gene expression]
GO:0016209 [antioxidant activity]
GO:0016491 [oxidoreductase activity]
GO:0042470 [melanosome]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0051920 [peroxiredoxin activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 199 aa
22.1 kDa 		No 0
PRDX1-002
ENSP00000407034
ENST00000447184
A0A0A0MSI0 [Direct mapping]
Peroxiredoxin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016209 [antioxidant activity]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 171 aa
19 kDa 		No 0
PRDX1-003
ENSP00000361150
ENST00000372079
A0A0A0MRQ5 [Direct mapping]
Peroxiredoxin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0051920 [peroxiredoxin activity]
GO:0055114 [oxidation-reduction process]
Show all
 97 aa
10.7 kDa 		No 0
PRDX1-004
ENSP00000389047
ENST00000424390
A0A0A0MSI0 [Direct mapping]
Peroxiredoxin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016209 [antioxidant activity]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 171 aa
19 kDa 		No 0
PRDX1-201
ENSP00000262746
ENST00000262746
Q06830 [Direct mapping]
Peroxiredoxin-1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001501 [skeletal system development]
GO:0001895 [retina homeostasis]
GO:0004601 [peroxidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006979 [response to oxidative stress]
GO:0008283 [cell proliferation]
GO:0008379 [thioredoxin peroxidase activity]
GO:0010467 [gene expression]
GO:0016209 [antioxidant activity]
GO:0016491 [oxidoreductase activity]
GO:0019430 [removal of superoxide radicals]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0034101 [erythrocyte homeostasis]
GO:0042267 [natural killer cell mediated cytotoxicity]
GO:0042345 [regulation of NF-kappaB import into nucleus]
GO:0042470 [melanosome]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0042802 [identical protein binding]
GO:0043209 [myelin sheath]
GO:0044822 [poly(A) RNA binding]
GO:0051920 [peroxiredoxin activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 199 aa
22.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.