Tissue expression of RNF146 - Summary - The Human Protein Atlas

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RNF146

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	RNF146
Gene description	Ring finger protein 146
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear and cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA027158 , HPA027209
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	RNF146 (HGNC Symbol)
Synonyms	dactylidin, dJ351K20.1, DKFZp434O1427
Description	Ring finger protein 146 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	q22.33
Chromosome location (bp)	127266610 - 127288567
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118518 (version 83.38)
Entrez gene	81847
UniProt	Q9NTX7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NTX7
Antibodypedia	RNF146 antibodies

PROTEIN BROWSER

RNF146-001	RNF146-002	RNF146-003	RNF146-005	RNF146-006	RNF146-008	RNF146-009	RNF146-011	RNF146-012	RNF146-013	RNF146-201	RNF146-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNF146-001 ENSP00000357297 ENST00000368314	Q9NTX7 [Direct mapping] E3 ubiquitin-protein ligase RNF146 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0008270 [zinc ion binding] GO:0016055 [Wnt signaling pathway] GO:0016874 [ligase activity] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0046872 [metal ion binding] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0070936 [protein K48-linked ubiquitination] GO:0072572 [poly-ADP-D-ribose binding] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	359 aa 38.9 kDa	No	0
RNF146-002 ENSP00000349253 ENST00000356799	V9GYY4 [Direct mapping] E3 ubiquitin-protein ligase RNF146 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.7 kDa	Yes	0
RNF146-003 ENSP00000476867 ENST00000477776	V9GYK9 [Direct mapping] E3 ubiquitin-protein ligase RNF146 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		42 aa 5 kDa	No	0
RNF146-005 ENSP00000477204 ENST00000476956	V9GYY4 [Direct mapping] E3 ubiquitin-protein ligase RNF146 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.7 kDa	Yes	0
RNF146-006 ENSP00000476424 ENST00000480444	V9GYK9 [Direct mapping] E3 ubiquitin-protein ligase RNF146 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		42 aa 5 kDa	No	0
RNF146-008 ENSP00000476814 ENST00000610153	Q9NTX7 [Direct mapping] E3 ubiquitin-protein ligase RNF146 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0008270 [zinc ion binding] GO:0016055 [Wnt signaling pathway] GO:0016874 [ligase activity] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0046872 [metal ion binding] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0070936 [protein K48-linked ubiquitination] GO:0072572 [poly-ADP-D-ribose binding] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	359 aa 38.9 kDa	No	0
RNF146-009 ENSP00000477019 ENST00000609447	V9GYK9 [Direct mapping] E3 ubiquitin-protein ligase RNF146 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		42 aa 5 kDa	No	0
RNF146-011 ENSP00000477168 ENST00000608991	Q9NTX7 [Direct mapping] E3 ubiquitin-protein ligase RNF146 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0008270 [zinc ion binding] GO:0016055 [Wnt signaling pathway] GO:0016874 [ligase activity] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0046872 [metal ion binding] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0070936 [protein K48-linked ubiquitination] GO:0072572 [poly-ADP-D-ribose binding] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	358 aa 38.8 kDa	No	0
RNF146-012 ENSP00000476888 ENST00000610162	A0A0G2JLL7 [Direct mapping] E3 ubiquitin-protein ligase RNF146 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		9 aa 0.9 kDa	No	0
RNF146-013 ENSP00000477440 ENST00000609944	V9GZ53 [Direct mapping] E3 ubiquitin-protein ligase RNF146 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		14 aa 1.6 kDa	No	0
RNF146-201 ENSP00000309365 ENST00000309649	Q9NTX7 [Direct mapping] E3 ubiquitin-protein ligase RNF146 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0008270 [zinc ion binding] GO:0016055 [Wnt signaling pathway] GO:0016874 [ligase activity] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0046872 [metal ion binding] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0070936 [protein K48-linked ubiquitination] GO:0072572 [poly-ADP-D-ribose binding] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	358 aa 38.8 kDa	No	0
RNF146-202 ENSP00000479890 ENST00000616343	Q9NTX7 [Direct mapping] E3 ubiquitin-protein ligase RNF146 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0008270 [zinc ion binding] GO:0016055 [Wnt signaling pathway] GO:0016874 [ligase activity] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0046872 [metal ion binding] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0070936 [protein K48-linked ubiquitination] GO:0072572 [poly-ADP-D-ribose binding] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	359 aa 38.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.