Expression of KCNJ8 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, inwardly rectifying subfamily J, member 8

Protein class

Disease related genes, FDA approved drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA031066

GENE INFORMATION
Gene name	KCNJ8 (HGNC Symbol)
Synonyms	Kir6.1
Description	Potassium channel, inwardly rectifying subfamily J, member 8 (HGNC Symbol)
Entrez gene summary	Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]
Chromosome	12
Cytoband	p12.1
Chromosome location (bp)	21764955 - 21775581
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121361 (version 83.38)
Entrez gene	3764
UniProt	Q15842 (UniProt - Evidence at protein level)
neXtProt	NX_Q15842
Antibodypedia	KCNJ8 antibodies

PROTEIN BROWSER

KCNJ8-001	KCNJ8-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNJ8-001 ENSP00000240662 ENST00000240662	Q15842 [Direct mapping] ATP-sensitive inward rectifier potassium channel 8 A0A024RAV6 [Target identity:100%; Query identity:100%] Potassium inwardly-rectifying channel, subfamily J, member 8, isoform CRA_a Show all	Transporters Transporter channels and pores Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0001822 [kidney development] GO:0005242 [inward rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007507 [heart development] GO:0008076 [voltage-gated potassium channel complex] GO:0008282 [ATP-sensitive potassium channel complex] GO:0009268 [response to pH] GO:0010107 [potassium ion import] GO:0015272 [ATP-activated inward rectifier potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017098 [sulfonylurea receptor binding] GO:0030016 [myofibril] GO:0032496 [response to lipopolysaccharide] GO:0034765 [regulation of ion transmembrane transport] GO:0042311 [vasodilation] GO:0042383 [sarcolemma] GO:0043231 [intracellular membrane-bounded organelle] GO:0043330 [response to exogenous dsRNA] GO:0051607 [defense response to virus] Show all	424 aa 48 kDa	No	2
KCNJ8-002 ENSP00000440012 ENST00000537950	F5GY12 [Direct mapping] ATP-sensitive inward rectifier potassium channel 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0010107 [potassium ion import] GO:0015272 [ATP-activated inward rectifier potassium channel activity] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] Show all	114 aa 13.3 kDa	No	1