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KCNJ8

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GENERAL INFORMATION

Gene name

 KCNJ8

Gene description

 Potassium channel, inwardly rectifying subfamily J, member 8

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (CACO-2, SH-SY5Y)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CACO-2, SH-SY5Y)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 KCNJ8 (HGNC Symbol)

Synonyms

 Kir6.1

Description

 Potassium channel, inwardly rectifying subfamily J, member 8 (HGNC Symbol)

Entrez gene summary

 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]

Chromosome

 12

Cytoband

 p12.1

Chromosome location (bp)

 21764955 - 21775581

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121361 (version 83.38)

Entrez gene

 3764

UniProt

 Q15842 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15842

Antibodypedia

 KCNJ8 antibodies

PROTEIN BROWSER
KCNJ8-001
KCNJ8-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNJ8-001
ENSP00000240662
ENST00000240662
Q15842 [Direct mapping]
ATP-sensitive inward rectifier potassium channel 8
A0A024RAV6 [Target identity:100%; Query identity:100%]
Potassium inwardly-rectifying channel, subfamily J, member 8, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Inwardly Rectifying Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001822 [kidney development]
GO:0005242 [inward rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007507 [heart development]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008282 [ATP-sensitive potassium channel complex]
GO:0009268 [response to pH]
GO:0010107 [potassium ion import]
GO:0015272 [ATP-activated inward rectifier potassium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017098 [sulfonylurea receptor binding]
GO:0030016 [myofibril]
GO:0032496 [response to lipopolysaccharide]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042311 [vasodilation]
GO:0042383 [sarcolemma]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043330 [response to exogenous dsRNA]
GO:0051607 [defense response to virus]
Show all
 424 aa
48 kDa 		No 2
KCNJ8-002
ENSP00000440012
ENST00000537950
F5GY12 [Direct mapping]
ATP-sensitive inward rectifier potassium channel 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0010107 [potassium ion import]
GO:0015272 [ATP-activated inward rectifier potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
Show all
 114 aa
13.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.