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Liver cancers, several prostate and endometrial cancers along with a few ovarian, breast and colorectal cancers weak to moderate granular cytoplasmic positivity. Remaining cancer tissues were negative.
Hepatocellular carcinomas showed moderate to strong cytoplasmic positivity while few cases endometrial cancers displayed moderate staining. Other cancer tissues were generally negative.
Hepatocellular and cases of prostate cancer showed moderate cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
CAT
Synonyms
Description
Catalase (HGNC Symbol)
Entrez gene summary
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)