We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
CAT
  • premium

    TISSUE

  • premium

    CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CAT

Gene description

Catalase

Protein class

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression with a granular pattern in hepatocytes, kidney tubules and a subset of immune cells.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA051282 , HPA055838 , CAB001515
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CAT

Synonyms

Description

Catalase (HGNC Symbol)

Entrez gene summary

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]

Chromosome

11

Cytoband

p13

Chromosome location (bp)

34438925 - 34472062

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121691 (version 83.38)

Entrez gene

847

UniProt

P04040 (UniProt - Evidence at protein level)

neXtProt

NX_P04040

Antibodypedia

CAT antibodies

PROTEIN BROWSER

CAT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAT-001
ENSP00000241052
ENST00000241052
P04040 [Direct mapping]
Catalase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001649 [osteoblast differentiation]
GO:0001657 [ureteric bud development]
GO:0001666 [response to hypoxia]
GO:0001822 [kidney development]
GO:0004046 [aminoacylase activity]
GO:0004096 [catalase activity]
GO:0005102 [receptor binding]
GO:0005615 [extracellular space]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0005764 [lysosome]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005782 [peroxisomal matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006144 [purine nucleobase metabolic process]
GO:0006195 [purine nucleotide catabolic process]
GO:0006641 [triglyceride metabolic process]
GO:0006979 [response to oxidative stress]
GO:0007568 [aging]
GO:0008203 [cholesterol metabolic process]
GO:0009060 [aerobic respiration]
GO:0009314 [response to radiation]
GO:0009411 [response to UV]
GO:0009636 [response to toxic substance]
GO:0009642 [response to light intensity]
GO:0009650 [UV protection]
GO:0010193 [response to ozone]
GO:0010288 [response to lead ion]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014823 [response to activity]
GO:0014854 [response to inactivity]
GO:0016020 [membrane]
GO:0016209 [antioxidant activity]
GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor]
GO:0019899 [enzyme binding]
GO:0020027 [hemoglobin metabolic process]
GO:0020037 [heme binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032355 [response to estradiol]
GO:0032868 [response to insulin]
GO:0033189 [response to vitamin A]
GO:0033197 [response to vitamin E]
GO:0033591 [response to L-ascorbic acid]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0046686 [response to cadmium ion]
GO:0046872 [metal ion binding]
GO:0050661 [NADP binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051262 [protein tetramerization]
GO:0051289 [protein homotetramerization]
GO:0051781 [positive regulation of cell division]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055093 [response to hyperoxia]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070542 [response to fatty acid]
GO:0071363 [cellular response to growth factor stimulus]
GO:0080184 [response to phenylpropanoid]
Show all
527 aa
59.8 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.