Tissue expression of C4BPA - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	C4BPA
Gene description	Complement component 4 binding protein, alpha
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (liver, lung)
GTEx:	Tissue enriched (liver)
FANTOM5:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Selective plasma positivity in extracellular matrix of several tissues, blood vessels and in bone marrow.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA000926 , HPA001578
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

N/A

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (liver, lung)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)

GENE INFORMATION
Gene name	C4BPA (HGNC Symbol)
Synonyms	C4BP
Description	Complement component 4 binding protein, alpha (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q32.2
Chromosome location (bp)	207104262 - 207144972
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123838 (version 83.38)
Entrez gene	722
UniProt	P04003 (UniProt - Evidence at protein level)
neXtProt	NX_P04003
Antibodypedia	C4BPA antibodies

PROTEIN BROWSER

C4BPA-001	C4BPA-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C4BPA-001 ENSP00000356037 ENST00000367070	P04003 [Direct mapping] C4b-binding protein alpha chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006958 [complement activation, classical pathway] GO:0030449 [regulation of complement activation] GO:0044216 [other organism cell] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0045732 [positive regulation of protein catabolic process] GO:0045959 [negative regulation of complement activation, classical pathway] GO:0072562 [blood microparticle] GO:1903027 [regulation of opsonization] Show all	597 aa 67 kDa	Yes	0
C4BPA-002 ENSP00000403386 ENST00000421786	A6PVY5 [Direct mapping] C4b-binding protein alpha chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		152 aa 16.9 kDa	Yes	0