Cell atlas - XPO5 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	XPO5
Gene description	Exportin 5
Protein class	Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 4 antibodies. CAB012357 , HPA018402 , HPA023959 , HPA029909
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
CAB012357	A-431	Nucleoplasm
CAB012357	A-431	Cytosol
CAB012357	U-2 OS	Nucleoplasm
CAB012357	U-2 OS	Cytosol
CAB012357	U-251 MG	Nucleoplasm
CAB012357	U-251 MG	Cytosol
HPA018402	A-431	Nucleoplasm
HPA018402	U-2 OS	Nucleoplasm
HPA018402	U-251 MG	Nucleoplasm
HPA023959	A-431	Nucleoplasm
HPA023959	U-2 OS	Nucleoplasm
HPA023959	U-2 OS	Cytosol
HPA023959	U-251 MG	Nucleoplasm
HPA029909	A-431	Nucleoplasm
HPA029909	U-2 OS	Nucleoplasm
HPA029909	U-251 MG	Nucleoplasm

siRNA VALIDATION

Relative fluorescence intensity (RFI)

Antibody

siRNA validation

Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 2

RFI

37%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail 10x	Thumbnail 40x	Antibody	Sample	Cell line
		HPA018402	siRNA 2	U-2 OS
		HPA018402	scrambled	U-2 OS

GENE INFORMATION
Gene name	XPO5 (HGNC Symbol)
Synonyms	KIAA1291
Description	Exportin 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	43522330 - 43576075
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124571 (version 83.38)
Entrez gene	57510
UniProt	Q9HAV4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HAV4
Antibodypedia	XPO5 antibodies

PROTEIN BROWSER

XPO5-001	XPO5-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
XPO5-001 ENSP00000265351 ENST00000265351	Q9HAV4 [Direct mapping] Exportin-5 Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006611 [protein export from nucleus] GO:0006886 [intracellular protein transport] GO:0008536 [Ran GTPase binding] GO:0008565 [protein transporter activity] GO:0010467 [gene expression] GO:0031047 [gene silencing by RNA] GO:0035281 [pre-miRNA export from nucleus] GO:0042565 [RNA nuclear export complex] GO:0044822 [poly(A) RNA binding] GO:0070883 [pre-miRNA binding] GO:1900370 [positive regulation of RNA interference] Show all	1204 aa 136.3 kDa	No	0
XPO5-015 ENSP00000387384 ENST00000455285	H0Y3W3 [Direct mapping] Exportin-5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		253 aa 28.3 kDa	No	0