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GNRH2

CANCER ATLAS

Gene description

 Gonadotropin-releasing hormone 2

Protein class

 Predicted secreted proteins

Protein evidence

 Evidence at transcript level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004338

GENE INFORMATION

Gene name

 GNRH2

Synonyms

Description

 Gonadotropin-releasing hormone 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a secreted peptide hormone and member of the gonadotropin-releasing hormone (GnRH) family of proteins. The encoded protein regulates reproductive function by stimulating the production and release of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The encoded protein may inhibit endometrial, ovarian, prostate, and breast cancer cell proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 3043622 - 3045747

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000125787 (version 83.38)

Entrez gene

 2797

UniProt

 O43555 (UniProt - Evidence at transcript level)

neXtProt

 NX_O43555

Antibodypedia

 GNRH2 antibodies

PROTEIN BROWSER
GNRH2-001
GNRH2-002
GNRH2-003
GNRH2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNRH2-001
ENSP00000245983
ENST00000245983
O43555 [Direct mapping]
Progonadoliberin-2 Gonadoliberin-2 GnRH-associated peptide 2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0000003 [reproduction]
GO:0005179 [hormone activity]
GO:0005183 [gonadotropin hormone-releasing hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0031530 [gonadotropin-releasing hormone receptor binding]
GO:0046883 [regulation of hormone secretion]
Show all
 120 aa
12.9 kDa 		Yes 0
GNRH2-002
ENSP00000369704
ENST00000380346
O43555 [Direct mapping]
Progonadoliberin-2 Gonadoliberin-2 GnRH-associated peptide 2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0000003 [reproduction]
GO:0005179 [hormone activity]
GO:0005183 [gonadotropin hormone-releasing hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0031530 [gonadotropin-releasing hormone receptor binding]
GO:0046883 [regulation of hormone secretion]
Show all
 112 aa
12.2 kDa 		Yes 0
GNRH2-003
ENSP00000369705
ENST00000380347
O43555 [Direct mapping]
Progonadoliberin-2 Gonadoliberin-2 GnRH-associated peptide 2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0000003 [reproduction]
GO:0005179 [hormone activity]
GO:0005183 [gonadotropin hormone-releasing hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0031530 [gonadotropin-releasing hormone receptor binding]
GO:0046883 [regulation of hormone secretion]
Show all
 113 aa
12.2 kDa 		Yes 0
GNRH2-004
ENSP00000352003
ENST00000359100
O43555 [Direct mapping]
Progonadoliberin-2 Gonadoliberin-2 GnRH-associated peptide 2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0000003 [reproduction]
GO:0005179 [hormone activity]
GO:0005183 [gonadotropin hormone-releasing hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0031530 [gonadotropin-releasing hormone receptor binding]
GO:0046883 [regulation of hormone secretion]
Show all
 113 aa
12.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.