Expression of FFAR2 in cancer - Summary

CANCER ATLAS

Gene description

Free fatty acid receptor 2

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA023985

GENE INFORMATION
Gene name	FFAR2 (HGNC Symbol)
Synonyms	FFA2R, GPR43
Description	Free fatty acid receptor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009]
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	35443907 - 35451767
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126262 (version 83.38)
Entrez gene	2867
UniProt	O15552 (UniProt - Evidence at protein level)
neXtProt	NX_O15552
Antibodypedia	FFAR2 antibodies

PROTEIN BROWSER

FFAR2-001	FFAR2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FFAR2-001 ENSP00000473159 ENST00000599180	O15552 [Direct mapping] Free fatty acid receptor 2 C6KYL4 [Target identity:100%; Query identity:100%] Free fatty acid receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0002232 [leukocyte chemotaxis involved in inflammatory response] GO:0002385 [mucosal immune response] GO:0002673 [regulation of acute inflammatory response] GO:0002720 [positive regulation of cytokine production involved in immune response] GO:0002752 [cell surface pattern recognition receptor signaling pathway] GO:0002879 [positive regulation of acute inflammatory response to non-antigenic stimulus] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008289 [lipid binding] GO:0016021 [integral component of membrane] GO:0019915 [lipid storage] GO:0032722 [positive regulation of chemokine production] GO:0042593 [glucose homeostasis] GO:0042995 [cell projection] GO:0045444 [fat cell differentiation] GO:0071398 [cellular response to fatty acid] GO:0090276 [regulation of peptide hormone secretion] GO:2000484 [positive regulation of interleukin-8 secretion] Show all	330 aa 37.1 kDa	No	7
FFAR2-201 ENSP00000246549 ENST00000246549	O15552 [Direct mapping] Free fatty acid receptor 2 C6KYL4 [Target identity:100%; Query identity:100%] Free fatty acid receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0002232 [leukocyte chemotaxis involved in inflammatory response] GO:0002385 [mucosal immune response] GO:0002673 [regulation of acute inflammatory response] GO:0002720 [positive regulation of cytokine production involved in immune response] GO:0002752 [cell surface pattern recognition receptor signaling pathway] GO:0002879 [positive regulation of acute inflammatory response to non-antigenic stimulus] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008289 [lipid binding] GO:0016021 [integral component of membrane] GO:0019915 [lipid storage] GO:0032722 [positive regulation of chemokine production] GO:0042593 [glucose homeostasis] GO:0045444 [fat cell differentiation] GO:0071398 [cellular response to fatty acid] GO:0090276 [regulation of peptide hormone secretion] GO:2000484 [positive regulation of interleukin-8 secretion] Show all	330 aa 37.1 kDa	No	7