Cell atlas - TUBA4A - The Human Protein Atlas

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TUBA4A

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules

Human cell
	Microtubules

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GENERAL INFORMATION
Gene name	TUBA4A
Gene description	Tubulin, alpha 4a
Protein class	Disease related genes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubules.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (validated)

DATA RELIABILITY
Reliability score	Validated based on 3 antibodies. CAB005887 , HPA039247 , HPA043684
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubules.

Main location

Microtubules (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039247	A-431	Microtubules
	HPA039247	U-2 OS	Microtubules
	HPA039247	U-251 MG	Microtubules
	HPA043684	PC-3	Microtubules
	HPA043684	U-2 OS	Microtubules
	HPA043684	U-251 MG	Microtubules
	CAB005887	A-431	Microtubules
	CAB005887	U-2 OS	Microtubules

GENE INFORMATION
Gene name	TUBA4A (HGNC Symbol)
Synonyms	FLJ30169, H2-ALPHA, TUBA1
Description	Tubulin, alpha 4a (HGNC Symbol)
Entrez gene summary	Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	219249711 - 219278170
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127824 (version 83.38)
Entrez gene	7277
UniProt	P68366 (UniProt - Evidence at protein level)
neXtProt	NX_P68366
Antibodypedia	TUBA4A antibodies

PROTEIN BROWSER

TUBA4A-001	TUBA4A-002	TUBA4A-003	TUBA4A-004	TUBA4A-009	TUBA4A-010	TUBA4A-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TUBA4A-001 ENSP00000248437 ENST00000248437	P68366 [Direct mapping] Tubulin alpha-4A chain Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0002576 [platelet degranulation] GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005576 [extracellular region] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0006996 [organelle organization] GO:0007017 [microtubule-based process] GO:0007596 [blood coagulation] GO:0019899 [enzyme binding] GO:0030168 [platelet activation] GO:0043234 [protein complex] GO:0044267 [cellular protein metabolic process] GO:0051084 ['de novo' posttranslational protein folding] GO:0051258 [protein polymerization] GO:0070062 [extracellular exosome] Show all	448 aa 49.9 kDa	No	0
TUBA4A-002 ENSP00000375938 ENST00000392088	P68366 [Direct mapping] Tubulin alpha-4A chain Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0002576 [platelet degranulation] GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005576 [extracellular region] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0006996 [organelle organization] GO:0007017 [microtubule-based process] GO:0007596 [blood coagulation] GO:0030168 [platelet activation] GO:0043234 [protein complex] GO:0044267 [cellular protein metabolic process] GO:0051084 ['de novo' posttranslational protein folding] GO:0051258 [protein polymerization] GO:0070062 [extracellular exosome] Show all	433 aa 48.3 kDa	No	0
TUBA4A-003 ENSP00000396061 ENST00000447205	C9JEV8 [Direct mapping] Tubulin alpha-4A chain Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] Show all	153 aa 16.9 kDa	No	0
TUBA4A-004 ENSP00000416992 ENST00000456818	C9JJQ8 [Direct mapping] Tubulin alpha-4A chain Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] Show all	198 aa 21.7 kDa	No	0
TUBA4A-009 ENSP00000404740 ENST00000425551	C9JDL2 [Direct mapping] Tubulin alpha-4A chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] Show all	120 aa 13.2 kDa	No	0
TUBA4A-010 ENSP00000408194 ENST00000427737	C9JQ00 [Direct mapping] Tubulin alpha-4A chain Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] Show all	180 aa 19.8 kDa	No	0
TUBA4A-011 ENSP00000396212 ENST00000398989	C9JDS9 [Direct mapping] Tubulin alpha-4A chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] GO:0043234 [protein complex] GO:0051258 [protein polymerization] Show all	156 aa 17.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.