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TUBA4A

GENERAL INFORMATION

Gene name

 TUBA4A

Gene description

 Tubulin, alpha 4a

Protein class

 Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 5 antibodies.
HPA039247 , HPA043684 , HPA063394 , CAB004621 , CAB005887
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin050100150200TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin01020304050RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0100200300400500Tags Per Million

GENE INFORMATION

Gene name

 TUBA4A (HGNC Symbol)

Synonyms

 FLJ30169, H2-ALPHA, TUBA1

Description

 Tubulin, alpha 4a (HGNC Symbol)

Entrez gene summary

 Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 219249711 - 219278170

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127824 (version 83.38)

Entrez gene

 7277

UniProt

 P68366 (UniProt - Evidence at protein level)

neXtProt

 NX_P68366

Antibodypedia

 TUBA4A antibodies

PROTEIN BROWSER
TUBA4A-001
TUBA4A-002
TUBA4A-003
TUBA4A-004
TUBA4A-009
TUBA4A-010
TUBA4A-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBA4A-001
ENSP00000248437
ENST00000248437
P68366 [Direct mapping]
Tubulin alpha-4A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0002576 [platelet degranulation]
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0007596 [blood coagulation]
GO:0019899 [enzyme binding]
GO:0030168 [platelet activation]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
GO:0070062 [extracellular exosome]
Show all
 448 aa
49.9 kDa 		No 0
TUBA4A-002
ENSP00000375938
ENST00000392088
P68366 [Direct mapping]
Tubulin alpha-4A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0002576 [platelet degranulation]
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0007596 [blood coagulation]
GO:0030168 [platelet activation]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
GO:0070062 [extracellular exosome]
Show all
 433 aa
48.3 kDa 		No 0
TUBA4A-003
ENSP00000396061
ENST00000447205
C9JEV8 [Direct mapping]
Tubulin alpha-4A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 153 aa
16.9 kDa 		No 0
TUBA4A-004
ENSP00000416992
ENST00000456818
C9JJQ8 [Direct mapping]
Tubulin alpha-4A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 198 aa
21.7 kDa 		No 0
TUBA4A-009
ENSP00000404740
ENST00000425551
C9JDL2 [Direct mapping]
Tubulin alpha-4A chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 120 aa
13.2 kDa 		No 0
TUBA4A-010
ENSP00000408194
ENST00000427737
C9JQ00 [Direct mapping]
Tubulin alpha-4A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 180 aa
19.8 kDa 		No 0
TUBA4A-011
ENSP00000396212
ENST00000398989
C9JDS9 [Direct mapping]
Tubulin alpha-4A chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
GO:0043234 [protein complex]
GO:0051258 [protein polymerization]
Show all
 156 aa
17.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.