Tissue expression of UBA1 - Summary - The Human Protein Atlas

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UBA1

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	UBA1
Gene description	Ubiquitin-like modifier activating enzyme 1
Protein class	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA000289 , CAB019435 , CAB073410
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	UBA1 (HGNC Symbol)
Synonyms	A1S9T, CFAP124, GXP1, POC20, UBE1, UBE1X
Description	Ubiquitin-like modifier activating enzyme 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p11.3
Chromosome location (bp)	47190861 - 47215128
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130985 (version 83.38)
Entrez gene	7317
UniProt	P22314 (UniProt - Evidence at protein level)
neXtProt	NX_P22314
Antibodypedia	UBA1 antibodies

PROTEIN BROWSER

UBA1-001	UBA1-002	UBA1-003	UBA1-004	UBA1-005	UBA1-006	UBA1-007	UBA1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBA1-001 ENSP00000338413 ENST00000335972	P22314 [Direct mapping] Ubiquitin-like modifier-activating enzyme 1 A0A024R1A3 [Target identity:100%; Query identity:100%] Ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing), isoform CRA_a Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000792 [heterochromatin] GO:0004839 [ubiquitin activating enzyme activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005765 [lysosomal membrane] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0008641 [small protein activating enzyme activity] GO:0010008 [endosome membrane] GO:0016567 [protein ubiquitination] GO:0030057 [desmosome] GO:0030867 [rough endoplasmic reticulum membrane] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	1058 aa 117.8 kDa	No	1
UBA1-002 ENSP00000366568 ENST00000377351	P22314 [Direct mapping] Ubiquitin-like modifier-activating enzyme 1 A0A024R1A3 [Target identity:100%; Query identity:100%] Ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing), isoform CRA_a Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000792 [heterochromatin] GO:0004839 [ubiquitin activating enzyme activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005765 [lysosomal membrane] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0008641 [small protein activating enzyme activity] GO:0010008 [endosome membrane] GO:0016567 [protein ubiquitination] GO:0030057 [desmosome] GO:0030867 [rough endoplasmic reticulum membrane] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	1058 aa 117.8 kDa	No	1
UBA1-003 ENSP00000366481 ENST00000377269	Q5JRR6 [Direct mapping] Ubiquitin-like modifier-activating enzyme 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008641 [small protein activating enzyme activity] Show all	506 aa 56.9 kDa	No	1
UBA1-004 ENSP00000415033 ENST00000412206	Q5JRR9 [Direct mapping] Ubiquitin-like modifier-activating enzyme 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006464 [cellular protein modification process] GO:0008641 [small protein activating enzyme activity] Show all	271 aa 29.2 kDa	No	0
UBA1-005 ENSP00000397816 ENST00000427561	Q5JRS1 [Direct mapping] Ubiquitin-like modifier-activating enzyme 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008641 [small protein activating enzyme activity] Show all	173 aa 18.6 kDa	No	0
UBA1-006 ENSP00000404796 ENST00000457753	Q5JRS3 [Direct mapping] Ubiquitin-like modifier-activating enzyme 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008641 [small protein activating enzyme activity] Show all	195 aa 20.7 kDa	No	0
UBA1-007 ENSP00000389583 ENST00000442035	Q5JRS0 [Direct mapping] Ubiquitin-like modifier-activating enzyme 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006464 [cellular protein modification process] GO:0008641 [small protein activating enzyme activity] Show all	284 aa 30.8 kDa	No	0
UBA1-008 ENSP00000401101 ENST00000451702	Q5JRS2 [Direct mapping] Ubiquitin-like modifier-activating enzyme 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0008641 [small protein activating enzyme activity] Show all	234 aa 25.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.