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SYNE1

CANCER ATLAS

Gene description

 Spectrin repeat containing, nuclear envelope 1

Protein class

 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA019113

GENE INFORMATION

Gene name

 SYNE1 (HGNC Symbol)

Synonyms

 8B, ARCA1, C6orf98, CPG2, dJ45H2.2, enaptin, KIAA0796, MYNE1, Nesp1, Nesprin-1, SCAR8, SYNE-1B

Description

 Spectrin repeat containing, nuclear envelope 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q25.2

Chromosome location (bp)

 152121684 - 152637801

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131018 (version 83.38)

Entrez gene

 23345

UniProt

 Q8NF91 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NF91

Antibodypedia

 SYNE1 antibodies

PROTEIN BROWSER
«
SYNE1-001
SYNE1-002
SYNE1-005
SYNE1-006
SYNE1-009
SYNE1-010
SYNE1-012
SYNE1-013
SYNE1-021
SYNE1-022
SYNE1-027
SYNE1-029
SYNE1-030
SYNE1-033
SYNE1-036
SYNE1-037
SYNE1-201
SYNE1-202
SYNE1-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYNE1-001
ENSP00000356224
ENST00000367255
Q8NF91 [Direct mapping]
Nesprin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005521 [lamin binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005640 [nuclear outer membrane]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0006997 [nucleus organization]
GO:0007030 [Golgi organization]
GO:0016021 [integral component of membrane]
GO:0030017 [sarcomere]
GO:0031965 [nuclear membrane]
GO:0034993 [LINC complex]
GO:0040023 [establishment of nucleus localization]
GO:0042692 [muscle cell differentiation]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044822 [poly(A) RNA binding]
GO:0045211 [postsynaptic membrane]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
GO:0090292 [nuclear matrix anchoring at nuclear membrane]
Show all
 8797 aa
1011.1 kDa 		No 1
SYNE1-002
ENSP00000396024
ENST00000423061
A0A0C4DG40 [Direct mapping]
Nesprin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
GO:0034993 [LINC complex]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 8749 aa
1005.2 kDa 		No 1
SYNE1-005
ENSP00000441052
ENST00000539504
Q5JV20 [Direct mapping]
Nesprin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
GO:0034993 [LINC complex]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 952 aa
108.9 kDa 		No 1
SYNE1-006
ENSP00000356220
ENST00000367251
H0Y325 [Direct mapping]
Nesprin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0031965 [nuclear membrane]
GO:0034993 [LINC complex]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 1654 aa
191.5 kDa 		No 0
SYNE1-009
ENSP00000356217
ENST00000367248
F5GXQ8 [Direct mapping]
Nesprin-1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0034993 [LINC complex]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 1433 aa
166.1 kDa 		No 0
SYNE1-010
ENSP00000356222
ENST00000367253
Q8NF91 [Direct mapping]
Nesprin-1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005521 [lamin binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005640 [nuclear outer membrane]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0006997 [nucleus organization]
GO:0007030 [Golgi organization]
GO:0016021 [integral component of membrane]
GO:0030017 [sarcomere]
GO:0031965 [nuclear membrane]
GO:0034993 [LINC complex]
GO:0042692 [muscle cell differentiation]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044822 [poly(A) RNA binding]
GO:0045211 [postsynaptic membrane]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
GO:0090292 [nuclear matrix anchoring at nuclear membrane]
Show all
 1725 aa
199.3 kDa 		No 0
SYNE1-012
ENSP00000390858
ENST00000454018
A0A0C4DH48 [Direct mapping]
Nesprin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 510 aa
58.6 kDa 		No 0
SYNE1-013
ENSP00000442805
ENST00000469439
H0YGD3 [Direct mapping]
Nesprin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 207 aa
23.8 kDa 		No 0
SYNE1-021
ENSP00000446021
ENST00000466159
F5H4Q0 [Direct mapping]
Nesprin-1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0034993 [LINC complex]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 754 aa
87.4 kDa 		No 0
SYNE1-022
ENSP00000438508
ENST00000495090
F5H422 [Direct mapping]
Nesprin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0034993 [LINC complex]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 612 aa
71.6 kDa 		No 0
SYNE1-027
ENSP00000346701
ENST00000354674
F8WAI0 [Direct mapping]
Nesprin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
GO:0034993 [LINC complex]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 975 aa
111.4 kDa 		No 1
SYNE1-029
ENSP00000414510
ENST00000413186
Q8NF91 [Direct mapping]
Nesprin-1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005521 [lamin binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005640 [nuclear outer membrane]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0006997 [nucleus organization]
GO:0007030 [Golgi organization]
GO:0016021 [integral component of membrane]
GO:0030017 [sarcomere]
GO:0031965 [nuclear membrane]
GO:0034993 [LINC complex]
GO:0042692 [muscle cell differentiation]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044822 [poly(A) RNA binding]
GO:0045211 [postsynaptic membrane]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
GO:0090292 [nuclear matrix anchoring at nuclear membrane]
Show all
 1443 aa
167.2 kDa 		No 0
SYNE1-030
ENSP00000441264
ENST00000537750
F5GYQ7 [Direct mapping]
Nesprin-1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0034993 [LINC complex]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 615 aa
71.1 kDa 		No 0
SYNE1-033
ENSP00000356226
ENST00000367257
H0Y326 [Direct mapping]
Nesprin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0031965 [nuclear membrane]
GO:0034993 [LINC complex]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 1355 aa
157.6 kDa 		No 0
SYNE1-036
ENSP00000437411
ENST00000540663
F5H6R8 [Direct mapping]
Nesprin-1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0034993 [LINC complex]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 242 aa
26.9 kDa 		No 0
SYNE1-037
ENSP00000443879
ENST00000537033
F5GZ83 [Direct mapping]
Nesprin-1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0034993 [LINC complex]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 195 aa
21.3 kDa 		No 0
SYNE1-201
ENSP00000341887
ENST00000341594
E7ENN3 [Direct mapping]
Nesprin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
GO:0034993 [LINC complex]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 8392 aa
964.8 kDa 		No 1
SYNE1-202
ENSP00000390975
ENST00000448038
E9PEL9 [Direct mapping]
Nesprin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0031965 [nuclear membrane]
Show all
 380 aa
43.1 kDa 		No 0
SYNE1-203
ENSP00000481873
ENST00000610489
A0A087WYJ5 [Direct mapping]
Nesprin-1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0034993 [LINC complex]
GO:0051015 [actin filament binding]
GO:0090286 [cytoskeletal anchoring at nuclear membrane]
Show all
 477 aa
54.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.