Tissue expression of SYNE1 - Summary - The Human Protein Atlas

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SYNE1

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SYNE1
Gene description	Spectrin repeat containing, nuclear envelope 1
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	19
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA019113
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SYNE1 (HGNC Symbol)
Synonyms	8B, ARCA1, C6orf98, CPG2, dJ45H2.2, enaptin, KIAA0796, MYNE1, Nesp1, Nesprin-1, SCAR8, SYNE-1B
Description	Spectrin repeat containing, nuclear envelope 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q25.2
Chromosome location (bp)	152121684 - 152637801
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131018 (version 83.38)
Entrez gene	23345
UniProt	Q8NF91 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NF91
Antibodypedia	SYNE1 antibodies

PROTEIN BROWSER

SYNE1-001	SYNE1-002	SYNE1-005	SYNE1-006	SYNE1-009	SYNE1-010	SYNE1-012	SYNE1-013	SYNE1-021	SYNE1-022	SYNE1-027	SYNE1-029	SYNE1-030	SYNE1-033	SYNE1-036	SYNE1-037	SYNE1-201	SYNE1-202	SYNE1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SYNE1-001 ENSP00000356224 ENST00000367255	Q8NF91 [Direct mapping] Nesprin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005640 [nuclear outer membrane] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005856 [cytoskeleton] GO:0006997 [nucleus organization] GO:0007030 [Golgi organization] GO:0016021 [integral component of membrane] GO:0030017 [sarcomere] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0040023 [establishment of nucleus localization] GO:0042692 [muscle cell differentiation] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044822 [poly(A) RNA binding] GO:0045211 [postsynaptic membrane] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] GO:0090292 [nuclear matrix anchoring at nuclear membrane] Show all	8797 aa 1011.1 kDa	No	1
SYNE1-002 ENSP00000396024 ENST00000423061	A0A0C4DG40 [Direct mapping] Nesprin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	8749 aa 1005.2 kDa	No	1
SYNE1-005 ENSP00000441052 ENST00000539504	Q5JV20 [Direct mapping] Nesprin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	952 aa 108.9 kDa	No	1
SYNE1-006 ENSP00000356220 ENST00000367251	H0Y325 [Direct mapping] Nesprin-1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	1654 aa 191.5 kDa	No	0
SYNE1-009 ENSP00000356217 ENST00000367248	F5GXQ8 [Direct mapping] Nesprin-1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	1433 aa 166.1 kDa	No	0
SYNE1-010 ENSP00000356222 ENST00000367253	Q8NF91 [Direct mapping] Nesprin-1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005640 [nuclear outer membrane] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005856 [cytoskeleton] GO:0006997 [nucleus organization] GO:0007030 [Golgi organization] GO:0016021 [integral component of membrane] GO:0030017 [sarcomere] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0042692 [muscle cell differentiation] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044822 [poly(A) RNA binding] GO:0045211 [postsynaptic membrane] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] GO:0090292 [nuclear matrix anchoring at nuclear membrane] Show all	1725 aa 199.3 kDa	No	0
SYNE1-012 ENSP00000390858 ENST00000454018	A0A0C4DH48 [Direct mapping] Nesprin-1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	510 aa 58.6 kDa	No	0
SYNE1-013 ENSP00000442805 ENST00000469439	H0YGD3 [Direct mapping] Nesprin-1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		207 aa 23.8 kDa	No	0
SYNE1-021 ENSP00000446021 ENST00000466159	F5H4Q0 [Direct mapping] Nesprin-1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	754 aa 87.4 kDa	No	0
SYNE1-022 ENSP00000438508 ENST00000495090	F5H422 [Direct mapping] Nesprin-1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	612 aa 71.6 kDa	No	0
SYNE1-027 ENSP00000346701 ENST00000354674	F8WAI0 [Direct mapping] Nesprin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	975 aa 111.4 kDa	No	1
SYNE1-029 ENSP00000414510 ENST00000413186	Q8NF91 [Direct mapping] Nesprin-1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005640 [nuclear outer membrane] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005856 [cytoskeleton] GO:0006997 [nucleus organization] GO:0007030 [Golgi organization] GO:0016021 [integral component of membrane] GO:0030017 [sarcomere] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0042692 [muscle cell differentiation] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044822 [poly(A) RNA binding] GO:0045211 [postsynaptic membrane] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] GO:0090292 [nuclear matrix anchoring at nuclear membrane] Show all	1443 aa 167.2 kDa	No	0
SYNE1-030 ENSP00000441264 ENST00000537750	F5GYQ7 [Direct mapping] Nesprin-1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	615 aa 71.1 kDa	No	0
SYNE1-033 ENSP00000356226 ENST00000367257	H0Y326 [Direct mapping] Nesprin-1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	1355 aa 157.6 kDa	No	0
SYNE1-036 ENSP00000437411 ENST00000540663	F5H6R8 [Direct mapping] Nesprin-1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	242 aa 26.9 kDa	No	0
SYNE1-037 ENSP00000443879 ENST00000537033	F5GZ83 [Direct mapping] Nesprin-1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	195 aa 21.3 kDa	No	0
SYNE1-201 ENSP00000341887 ENST00000341594	E7ENN3 [Direct mapping] Nesprin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	8392 aa 964.8 kDa	No	1
SYNE1-202 ENSP00000390975 ENST00000448038	E9PEL9 [Direct mapping] Nesprin-1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0031965 [nuclear membrane] Show all	380 aa 43.1 kDa	No	0
SYNE1-203 ENSP00000481873 ENST00000610489	A0A087WYJ5 [Direct mapping] Nesprin-1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0034993 [LINC complex] GO:0051015 [actin filament binding] GO:0090286 [cytoskeletal anchoring at nuclear membrane] Show all	477 aa 54.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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