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Strong cytoplasmic immunoreactivity was observed in melanomas along with few gliomas and urothelial cancers. Thyroid cancers along with several endometrial and renal cancers displayed moderate to strong cytoplasmic and/or membranous staining. Remaining cancers were negative.
Most cancers displayed moderate cytoplasmic immunoreactivity. A few cases of colorectal, endometrial, gastric and pancreatic cancers showed strong staining. Skin cancers were weakly stained.
GENE INFORMATION
Gene name
PPFIA1 (HGNC Symbol)
Synonyms
LIP.1, LIPRIN
Description
Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]