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PPFIA1

GENERAL INFORMATION

Gene name

 PPFIA1

Gene description

 Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA042271 , CAB017032
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PPFIA1 (HGNC Symbol)

Synonyms

 LIP.1, LIPRIN

Description

 Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.3

Chromosome location (bp)

 70270700 - 70384403

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131626 (version 83.38)

Entrez gene

 8500

UniProt

 Q13136 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13136

Antibodypedia

 PPFIA1 antibodies

PROTEIN BROWSER
PPFIA1-001
PPFIA1-002
PPFIA1-008
PPFIA1-009
PPFIA1-013
PPFIA1-018
PPFIA1-023

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPFIA1-001
ENSP00000253925
ENST00000253925
Q13136 [Direct mapping]
Liprin-alpha-1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0014047 [glutamate secretion]
GO:0048786 [presynaptic active zone]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0090005 [negative regulation of establishment of protein localization to plasma membrane]
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 1202 aa
135.8 kDa 		No 0
PPFIA1-002
ENSP00000374198
ENST00000389547
Q13136 [Direct mapping]
Liprin-alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0014047 [glutamate secretion]
GO:0048786 [presynaptic active zone]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0090005 [negative regulation of establishment of protein localization to plasma membrane]
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 1185 aa
134 kDa 		No 0
PPFIA1-008
ENSP00000432722
ENST00000530746
E9PPF6 [Direct mapping]
Liprin-alpha-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 158 aa
17.6 kDa 		No 0
PPFIA1-009
ENSP00000432065
ENST00000532024
E9PID5 [Direct mapping]
Liprin-alpha-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 99 aa
10.8 kDa 		No 0
PPFIA1-013
ENSP00000433114
ENST00000530798
H0YD72 [Direct mapping]
Liprin-alpha-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 237 aa
26 kDa 		No 0
PPFIA1-018
ENSP00000434445
ENST00000528750
H0YDW2 [Direct mapping]
Liprin-alpha-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 390 aa
42.2 kDa 		No 0
PPFIA1-023
ENSP00000434692
ENST00000528853
H0YDZ8 [Direct mapping]
Liprin-alpha-1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0016021 [integral component of membrane]
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 98 aa
11.4 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.