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DNAJB1

CANCER ATLAS

Gene description

 DnaJ (Hsp40) homolog, subfamily B, member 1

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA063247
CAB017450

GENE INFORMATION

Gene name

 DNAJB1 (HGNC Symbol)

Synonyms

 Hsp40, HSPF1, RSPH16B, Sis1

Description

 DnaJ (Hsp40) homolog, subfamily B, member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Chromosome

 19

Cytoband

 p13.12

Chromosome location (bp)

 14514770 - 14529770

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132002 (version 83.38)

Entrez gene

 3337

UniProt

 P25685 (UniProt - Evidence at protein level)

neXtProt

 NX_P25685

Antibodypedia

 DNAJB1 antibodies

PROTEIN BROWSER
DNAJB1-001
DNAJB1-003
DNAJB1-005
DNAJB1-006
DNAJB1-007
DNAJB1-008
DNAJB1-009
DNAJB1-010
DNAJB1-011
DNAJB1-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNAJB1-001
ENSP00000254322
ENST00000254322
P25685 [Direct mapping]
DnaJ homolog subfamily B member 1
Q6FHS4 [Target identity:100%; Query identity:100%]
DNAJB1 protein; DnaJ (Hsp40) homolog, subfamily B, member 1, isoform CRA_a; cDNA, FLJ93008, Homo sapiens DnaJ (Hsp40) homolog, subfamily B, member 1 (DNAJB1),mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001671 [ATPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006986 [response to unfolded protein]
GO:0030544 [Hsp70 protein binding]
GO:0032781 [positive regulation of ATPase activity]
GO:0034605 [cellular response to heat]
GO:0051082 [unfolded protein binding]
GO:0051085 [chaperone mediated protein folding requiring cofactor]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0070062 [extracellular exosome]
GO:0070389 [chaperone cofactor-dependent protein refolding]
GO:0090084 [negative regulation of inclusion body assembly]
GO:1900034 [regulation of cellular response to heat]
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 340 aa
38 kDa 		No 0
DNAJB1-003
ENSP00000444212
ENST00000396969
P25685 [Direct mapping]
DnaJ homolog subfamily B member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001671 [ATPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006986 [response to unfolded protein]
GO:0030544 [Hsp70 protein binding]
GO:0032781 [positive regulation of ATPase activity]
GO:0034605 [cellular response to heat]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0070062 [extracellular exosome]
GO:0070389 [chaperone cofactor-dependent protein refolding]
GO:0090084 [negative regulation of inclusion body assembly]
GO:1900034 [regulation of cellular response to heat]
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 240 aa
27 kDa 		No 0
DNAJB1-005
ENSP00000471073
ENST00000598235
M0R080 [Direct mapping]
DnaJ homolog subfamily B member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
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 183 aa
20.5 kDa 		No 0
DNAJB1-006
ENSP00000469221
ENST00000595139
M0QXK0 [Direct mapping]
DnaJ homolog subfamily B member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
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 162 aa
17.7 kDa 		No 0
DNAJB1-007
ENSP00000472886
ENST00000598692
M0R128 [Direct mapping]
DnaJ homolog subfamily B member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 80 aa
8.9 kDa 		No 0
DNAJB1-008
ENSP00000470460
ENST00000594099
M0QZD0 [Direct mapping]
DnaJ homolog subfamily B member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
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 107 aa
12.1 kDa 		No 0
DNAJB1-009
ENSP00000471798
ENST00000601533
M0R1D6 [Direct mapping]
DnaJ homolog subfamily B member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
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 91 aa
10.3 kDa 		No 0
DNAJB1-010
ENSP00000470596
ENST00000595992
M0QYT3 [Direct mapping]
DnaJ homolog subfamily B member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 116 aa
13.1 kDa 		No 0
DNAJB1-011
ENSP00000471603
ENST00000596075
M0R128 [Direct mapping]
DnaJ homolog subfamily B member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
Show all
 80 aa
8.9 kDa 		No 0
DNAJB1-013
ENSP00000470063
ENST00000596853
M0QYT3 [Direct mapping]
DnaJ homolog subfamily B member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 116 aa
13.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.