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DNAJB1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

DNAJB1

Gene description

DnaJ (Hsp40) homolog, subfamily B, member 1

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General nuclear and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA063247 , CAB017450
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin0100200300400TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin050100150200250RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina02004006008001,0001,200Tags Per Million

GENE INFORMATION

Gene name

DNAJB1 (HGNC Symbol)

Synonyms

Hsp40, HSPF1, RSPH16B, Sis1

Description

DnaJ (Hsp40) homolog, subfamily B, member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Chromosome

19

Cytoband

p13.12

Chromosome location (bp)

14514770 - 14529770

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132002 (version 83.38)

Entrez gene

3337

UniProt

P25685 (UniProt - Evidence at protein level)

neXtProt

NX_P25685

Antibodypedia

DNAJB1 antibodies

PROTEIN BROWSER

DNAJB1-001
DNAJB1-003
DNAJB1-005
DNAJB1-006
DNAJB1-007
DNAJB1-008
DNAJB1-009
DNAJB1-010
DNAJB1-011
DNAJB1-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DNAJB1-001
ENSP00000254322
ENST00000254322
P25685 [Direct mapping]
DnaJ homolog subfamily B member 1
Q6FHS4 [Target identity:100%; Query identity:100%]
DNAJB1 protein; DnaJ (Hsp40) homolog, subfamily B, member 1, isoform CRA_a; cDNA, FLJ93008, Homo sapiens DnaJ (Hsp40) homolog, subfamily B, member 1 (DNAJB1),mRNA
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001671 [ATPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006986 [response to unfolded protein]
GO:0030544 [Hsp70 protein binding]
GO:0032781 [positive regulation of ATPase activity]
GO:0034605 [cellular response to heat]
GO:0051082 [unfolded protein binding]
GO:0051085 [chaperone mediated protein folding requiring cofactor]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0070062 [extracellular exosome]
GO:0070389 [chaperone cofactor-dependent protein refolding]
GO:0090084 [negative regulation of inclusion body assembly]
GO:1900034 [regulation of cellular response to heat]
Show all
340 aa
38 kDa
No 0
DNAJB1-003
ENSP00000444212
ENST00000396969
P25685 [Direct mapping]
DnaJ homolog subfamily B member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001671 [ATPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006986 [response to unfolded protein]
GO:0030544 [Hsp70 protein binding]
GO:0032781 [positive regulation of ATPase activity]
GO:0034605 [cellular response to heat]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0070062 [extracellular exosome]
GO:0070389 [chaperone cofactor-dependent protein refolding]
GO:0090084 [negative regulation of inclusion body assembly]
GO:1900034 [regulation of cellular response to heat]
Show all
240 aa
27 kDa
No 0
DNAJB1-005
ENSP00000471073
ENST00000598235
M0R080 [Direct mapping]
DnaJ homolog subfamily B member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
183 aa
20.5 kDa
No 0
DNAJB1-006
ENSP00000469221
ENST00000595139
M0QXK0 [Direct mapping]
DnaJ homolog subfamily B member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
162 aa
17.7 kDa
No 0
DNAJB1-007
ENSP00000472886
ENST00000598692
M0R128 [Direct mapping]
DnaJ homolog subfamily B member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
Show all
80 aa
8.9 kDa
No 0
DNAJB1-008
ENSP00000470460
ENST00000594099
M0QZD0 [Direct mapping]
DnaJ homolog subfamily B member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
107 aa
12.1 kDa
No 0
DNAJB1-009
ENSP00000471798
ENST00000601533
M0R1D6 [Direct mapping]
DnaJ homolog subfamily B member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
91 aa
10.3 kDa
No 0
DNAJB1-010
ENSP00000470596
ENST00000595992
M0QYT3 [Direct mapping]
DnaJ homolog subfamily B member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
116 aa
13.1 kDa
No 0
DNAJB1-011
ENSP00000471603
ENST00000596075
M0R128 [Direct mapping]
DnaJ homolog subfamily B member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
Show all
80 aa
8.9 kDa
No 0
DNAJB1-013
ENSP00000470063
ENST00000596853
M0QYT3 [Direct mapping]
DnaJ homolog subfamily B member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
116 aa
13.1 kDa
No 0

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The Human Protein Atlas project is funded
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