Cell atlas - DNAJB1 - The Human Protein Atlas

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DNAJB1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	DNAJB1
Gene description	DnaJ (Hsp40) homolog, subfamily B, member 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated)
Additional location	In addition localized to the Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. CAB017450 , HPA063247
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

Nucleus (validated)

Additional location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB017450	A-431	Nucleoplasm
	CAB017450	A-431	Cytosol
	CAB017450	U-2 OS	Nucleoplasm
	CAB017450	U-2 OS	Cytosol
	CAB017450	U-251 MG	Nucleoplasm
	CAB017450	U-251 MG	Cytosol
	HPA063247	A549	Nucleus
	HPA063247	PC-3	Nucleus
	HPA063247	U-2 OS	Nucleus

GENE INFORMATION
Gene name	DNAJB1 (HGNC Symbol)
Synonyms	Hsp40, HSPF1, RSPH16B, Sis1
Description	DnaJ (Hsp40) homolog, subfamily B, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Chromosome	19
Cytoband	p13.12
Chromosome location (bp)	14514770 - 14529770
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132002 (version 83.38)
Entrez gene	3337
UniProt	P25685 (UniProt - Evidence at protein level)
neXtProt	NX_P25685
Antibodypedia	DNAJB1 antibodies

PROTEIN BROWSER

DNAJB1-001	DNAJB1-003	DNAJB1-005	DNAJB1-006	DNAJB1-007	DNAJB1-008	DNAJB1-009	DNAJB1-010	DNAJB1-011	DNAJB1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNAJB1-001 ENSP00000254322 ENST00000254322	P25685 [Direct mapping] DnaJ homolog subfamily B member 1 Q6FHS4 [Target identity:100%; Query identity:100%] DNAJB1 protein; DnaJ (Hsp40) homolog, subfamily B, member 1, isoform CRA_a; cDNA, FLJ93008, Homo sapiens DnaJ (Hsp40) homolog, subfamily B, member 1 (DNAJB1),mRNA Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001671 [ATPase activator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0006457 [protein folding] GO:0006986 [response to unfolded protein] GO:0030544 [Hsp70 protein binding] GO:0032781 [positive regulation of ATPase activity] GO:0034605 [cellular response to heat] GO:0051082 [unfolded protein binding] GO:0051085 [chaperone mediated protein folding requiring cofactor] GO:0051087 [chaperone binding] GO:0051117 [ATPase binding] GO:0070062 [extracellular exosome] GO:0070389 [chaperone cofactor-dependent protein refolding] GO:0090084 [negative regulation of inclusion body assembly] GO:1900034 [regulation of cellular response to heat] Show all	340 aa 38 kDa	No	0
DNAJB1-003 ENSP00000444212 ENST00000396969	P25685 [Direct mapping] DnaJ homolog subfamily B member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001671 [ATPase activator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0006457 [protein folding] GO:0006986 [response to unfolded protein] GO:0030544 [Hsp70 protein binding] GO:0032781 [positive regulation of ATPase activity] GO:0034605 [cellular response to heat] GO:0051082 [unfolded protein binding] GO:0051087 [chaperone binding] GO:0051117 [ATPase binding] GO:0070062 [extracellular exosome] GO:0070389 [chaperone cofactor-dependent protein refolding] GO:0090084 [negative regulation of inclusion body assembly] GO:1900034 [regulation of cellular response to heat] Show all	240 aa 27 kDa	No	0
DNAJB1-005 ENSP00000471073 ENST00000598235	M0R080 [Direct mapping] DnaJ homolog subfamily B member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	183 aa 20.5 kDa	No	0
DNAJB1-006 ENSP00000469221 ENST00000595139	M0QXK0 [Direct mapping] DnaJ homolog subfamily B member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	162 aa 17.7 kDa	No	0
DNAJB1-007 ENSP00000472886 ENST00000598692	M0R128 [Direct mapping] DnaJ homolog subfamily B member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	80 aa 8.9 kDa	No	0
DNAJB1-008 ENSP00000470460 ENST00000594099	M0QZD0 [Direct mapping] DnaJ homolog subfamily B member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	107 aa 12.1 kDa	No	0
DNAJB1-009 ENSP00000471798 ENST00000601533	M0R1D6 [Direct mapping] DnaJ homolog subfamily B member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	91 aa 10.3 kDa	No	0
DNAJB1-010 ENSP00000470596 ENST00000595992	M0QYT3 [Direct mapping] DnaJ homolog subfamily B member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	116 aa 13.1 kDa	No	0
DNAJB1-011 ENSP00000471603 ENST00000596075	M0R128 [Direct mapping] DnaJ homolog subfamily B member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	80 aa 8.9 kDa	No	0
DNAJB1-013 ENSP00000470063 ENST00000596853	M0QYT3 [Direct mapping] DnaJ homolog subfamily B member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	116 aa 13.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.