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PEBP4

GENERAL INFORMATION

Gene name

 PEBP4

Gene description

 Phosphatidylethanolamine-binding protein 4

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (epididymis, skeletal muscle, lung)
GTEx:Tissue enhanced (heart muscle, skeletal muscle, lung)
FANTOM5:Tissue enhanced (skeletal muscle, heart muscle, epididymis)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA025064
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (epididymis, skeletal muscle, lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, skeletal muscle, lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle, heart muscle, epididymis)

GENE INFORMATION

Gene name

 PEBP4 (HGNC Symbol)

Synonyms

 CORK1, hPEBP4, MGC22776

Description

 Phosphatidylethanolamine-binding protein 4 (HGNC Symbol)

Entrez gene summary

 The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008]

Chromosome

 8

Cytoband

 p21.3

Chromosome location (bp)

 22713251 - 23000000

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134020 (version 83.38)

Entrez gene

 157310

UniProt

 Q96S96 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96S96

Antibodypedia

 PEBP4 antibodies

PROTEIN BROWSER
PEBP4-001
PEBP4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PEBP4-001
ENSP00000256404
ENST00000256404
Q96S96 [Direct mapping]
Phosphatidylethanolamine-binding protein 4
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0070062 [extracellular exosome]
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 227 aa
25.7 kDa 		Yes 0
PEBP4-002
ENSP00000429414
ENST00000522278
E5RIK3 [Direct mapping]
Phosphatidylethanolamine-binding protein 4
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   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016021 [integral component of membrane]
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 93 aa
10 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.