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Gene name

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In atlas

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Method

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Searches

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Detectable

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CCNB1
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    CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CCNB1

Gene description

Cyclin B1

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in proliferating cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA061448 , CAB000115 , CAB003804
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin010203040506070TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin05101520RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0102030405060Tags Per Million

GENE INFORMATION

Gene name

CCNB1 (HGNC Symbol)

Synonyms

CCNB

Description

Cyclin B1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q13.2

Chromosome location (bp)

69167010 - 69178245

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134057 (version 83.38)

Entrez gene

891

UniProt

P14635 (UniProt - Evidence at protein level)

neXtProt

NX_P14635

Antibodypedia

CCNB1 antibodies

PROTEIN BROWSER

CCNB1-001
CCNB1-002
CCNB1-003
CCNB1-005
CCNB1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCNB1-001
ENSP00000256442
ENST00000256442
P14635 [Direct mapping]
G2/mitotic-specific cyclin-B1
Show all
Transporters
   Transporter channels and pores
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0000942 [condensed nuclear chromosome outer kinetochore]
GO:0001556 [oocyte maturation]
GO:0001701 [in utero embryonic development]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0005113 [patched binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006461 [protein complex assembly]
GO:0006468 [protein phosphorylation]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007080 [mitotic metaphase plate congression]
GO:0007283 [spermatogenesis]
GO:0009612 [response to mechanical stimulus]
GO:0009636 [response to toxic substance]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0019901 [protein kinase binding]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031442 [positive regulation of mRNA 3'-end processing]
GO:0033129 [positive regulation of histone phosphorylation]
GO:0035173 [histone kinase activity]
GO:0042246 [tissue regeneration]
GO:0042493 [response to drug]
GO:0043148 [mitotic spindle stabilization]
GO:0045787 [positive regulation of cell cycle]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046680 [response to DDT]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048565 [digestive tract development]
GO:0051301 [cell division]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051726 [regulation of cell cycle]
GO:0051987 [positive regulation of attachment of spindle microtubules to kinetochore]
GO:0055015 [ventricular cardiac muscle cell development]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060623 [regulation of chromosome condensation]
GO:0071283 [cellular response to iron(III) ion]
GO:0071398 [cellular response to fatty acid]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071456 [cellular response to hypoxia]
GO:0090266 [regulation of mitotic cell cycle spindle assembly checkpoint]
GO:2000775 [histone H3-S10 phosphorylation involved in chromosome condensation]
Show all
433 aa
48.3 kDa
No 0
CCNB1-002
ENSP00000424588
ENST00000505500
P14635 [Direct mapping]
G2/mitotic-specific cyclin-B1
Show all
Transporters
   Transporter channels and pores
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0000942 [condensed nuclear chromosome outer kinetochore]
GO:0005113 [patched binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007080 [mitotic metaphase plate congression]
GO:0019901 [protein kinase binding]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0043148 [mitotic spindle stabilization]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0051301 [cell division]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051726 [regulation of cell cycle]
GO:0051987 [positive regulation of attachment of spindle microtubules to kinetochore]
GO:0090266 [regulation of mitotic cell cycle spindle assembly checkpoint]
Show all
396 aa
44.1 kDa
No 0
CCNB1-003
ENSP00000423387
ENST00000506572
E9PC90 [Direct mapping]
G2/mitotic-specific cyclin-B1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
Show all
401 aa
44.9 kDa
No 0
CCNB1-005
ENSP00000426092
ENST00000508407
D6RHI0 [Direct mapping]
G2/mitotic-specific cyclin-B1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
244 aa
26.8 kDa
No 0
CCNB1-006
ENSP00000426230
ENST00000507798
H0YA62 [Direct mapping]
G2/mitotic-specific cyclin-B1
Show all
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
Show all
185 aa
21.5 kDa
No 0

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The Human Protein Atlas project is funded
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