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SPIRE1

CANCER ATLAS

Gene description

 Spire-type actin nucleation factor 1

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040737
HPA040942

GENE INFORMATION

Gene name

 SPIRE1 (HGNC Symbol)

Synonyms

 KIAA1135, spir-1

Description

 Spire-type actin nucleation factor 1 (HGNC Symbol)

Entrez gene summary

 Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).[supplied by OMIM, Mar 2008]

Chromosome

 18

Cytoband

 p11.21

Chromosome location (bp)

 12446512 - 12658134

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134278 (version 83.38)

Entrez gene

 56907

UniProt

 Q08AE8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08AE8

Antibodypedia

 SPIRE1 antibodies

PROTEIN BROWSER
SPIRE1-001
SPIRE1-002
SPIRE1-004
SPIRE1-005
SPIRE1-006
SPIRE1-010
SPIRE1-011
SPIRE1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPIRE1-001
ENSP00000387266
ENST00000409402
Q08AE8 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030036 [actin cytoskeleton organization]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0032154 [cleavage furrow]
GO:0036089 [cleavage furrow formation]
GO:0040038 [polar body extrusion after meiotic divisions]
GO:0045010 [actin nucleation]
GO:0046907 [intracellular transport]
GO:0048193 [Golgi vesicle transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051295 [establishment of meiotic spindle localization]
GO:0070649 [formin-nucleated actin cable assembly]
Show all
 756 aa
85.5 kDa 		No 0
SPIRE1-002
ENSP00000387226
ENST00000410092
Q08AE8 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030036 [actin cytoskeleton organization]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0032154 [cleavage furrow]
GO:0036089 [cleavage furrow formation]
GO:0040038 [polar body extrusion after meiotic divisions]
GO:0045010 [actin nucleation]
GO:0046907 [intracellular transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051295 [establishment of meiotic spindle localization]
GO:0070649 [formin-nucleated actin cable assembly]
Show all
 742 aa
84 kDa 		No 0
SPIRE1-004
ENSP00000467943
ENST00000462226
K7EQR2 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016192 [vesicle-mediated transport]
GO:0045010 [actin nucleation]
Show all
 122 aa
13.7 kDa 		No 0
SPIRE1-005
ENSP00000309661
ENST00000309836
J3KNG6 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016192 [vesicle-mediated transport]
GO:0045010 [actin nucleation]
Show all
 545 aa
62.9 kDa 		No 0
SPIRE1-006
ENSP00000401392
ENST00000449797
C9JYR7 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016192 [vesicle-mediated transport]
GO:0045010 [actin nucleation]
Show all
 197 aa
22.8 kDa 		No 0
SPIRE1-010
ENSP00000407050
ENST00000453447
Q08AE8 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030036 [actin cytoskeleton organization]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0032154 [cleavage furrow]
GO:0036089 [cleavage furrow formation]
GO:0040038 [polar body extrusion after meiotic divisions]
GO:0045010 [actin nucleation]
GO:0046907 [intracellular transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051295 [establishment of meiotic spindle localization]
GO:0070649 [formin-nucleated actin cable assembly]
Show all
 622 aa
71.6 kDa 		No 0
SPIRE1-011
ENSP00000467103
ENST00000497844
K7ENV1 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016192 [vesicle-mediated transport]
GO:0045010 [actin nucleation]
Show all
 147 aa
16.4 kDa 		No 0
SPIRE1-201
ENSP00000486927
ENST00000626255
A0A0D9SFV5 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016192 [vesicle-mediated transport]
GO:0045010 [actin nucleation]
Show all
 622 aa
71.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.