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SPIRE1

GENERAL INFORMATION

Gene name

 SPIRE1

Gene description

 Spire-type actin nucleation factor 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA040737 , HPA040942
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SPIRE1 (HGNC Symbol)

Synonyms

 KIAA1135, spir-1

Description

 Spire-type actin nucleation factor 1 (HGNC Symbol)

Entrez gene summary

 Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).[supplied by OMIM, Mar 2008]

Chromosome

 18

Cytoband

 p11.21

Chromosome location (bp)

 12446512 - 12658134

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134278 (version 83.38)

Entrez gene

 56907

UniProt

 Q08AE8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08AE8

Antibodypedia

 SPIRE1 antibodies

PROTEIN BROWSER
SPIRE1-001
SPIRE1-002
SPIRE1-004
SPIRE1-005
SPIRE1-006
SPIRE1-010
SPIRE1-011
SPIRE1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPIRE1-001
ENSP00000387266
ENST00000409402
Q08AE8 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030036 [actin cytoskeleton organization]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0032154 [cleavage furrow]
GO:0036089 [cleavage furrow formation]
GO:0040038 [polar body extrusion after meiotic divisions]
GO:0045010 [actin nucleation]
GO:0046907 [intracellular transport]
GO:0048193 [Golgi vesicle transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051295 [establishment of meiotic spindle localization]
GO:0070649 [formin-nucleated actin cable assembly]
Show all
 756 aa
85.5 kDa 		No 0
SPIRE1-002
ENSP00000387226
ENST00000410092
Q08AE8 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030036 [actin cytoskeleton organization]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0032154 [cleavage furrow]
GO:0036089 [cleavage furrow formation]
GO:0040038 [polar body extrusion after meiotic divisions]
GO:0045010 [actin nucleation]
GO:0046907 [intracellular transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051295 [establishment of meiotic spindle localization]
GO:0070649 [formin-nucleated actin cable assembly]
Show all
 742 aa
84 kDa 		No 0
SPIRE1-004
ENSP00000467943
ENST00000462226
K7EQR2 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016192 [vesicle-mediated transport]
GO:0045010 [actin nucleation]
Show all
 122 aa
13.7 kDa 		No 0
SPIRE1-005
ENSP00000309661
ENST00000309836
J3KNG6 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016192 [vesicle-mediated transport]
GO:0045010 [actin nucleation]
Show all
 545 aa
62.9 kDa 		No 0
SPIRE1-006
ENSP00000401392
ENST00000449797
C9JYR7 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016192 [vesicle-mediated transport]
GO:0045010 [actin nucleation]
Show all
 197 aa
22.8 kDa 		No 0
SPIRE1-010
ENSP00000407050
ENST00000453447
Q08AE8 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030036 [actin cytoskeleton organization]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0032154 [cleavage furrow]
GO:0036089 [cleavage furrow formation]
GO:0040038 [polar body extrusion after meiotic divisions]
GO:0045010 [actin nucleation]
GO:0046907 [intracellular transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051295 [establishment of meiotic spindle localization]
GO:0070649 [formin-nucleated actin cable assembly]
Show all
 622 aa
71.6 kDa 		No 0
SPIRE1-011
ENSP00000467103
ENST00000497844
K7ENV1 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016192 [vesicle-mediated transport]
GO:0045010 [actin nucleation]
Show all
 147 aa
16.4 kDa 		No 0
SPIRE1-201
ENSP00000486927
ENST00000626255
A0A0D9SFV5 [Direct mapping]
Protein spire homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016192 [vesicle-mediated transport]
GO:0045010 [actin nucleation]
Show all
 622 aa
71.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.