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Moderate cytoplasmic staining was observed in most malignant tissues. A majority of malignant lymphomas, renal, cervical and endometrial cancers were weakly stained or negative.
Moderate cytoplasmic positivity was observed in a few cases of breast and skin cancers. One case of malignant gliomas were strongly stained. Malignant cells in general were weakly stained or negative.
This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
