Cell atlas - NAV1 - The Human Protein Atlas

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NAV1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules

Human cell
	Microtubules

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GENERAL INFORMATION
Gene name	NAV1
Gene description	Neuron navigator 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubules.
RNA cell category	Cell line enhanced (TIME)
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA018127
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubules.

Main location

Microtubules (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA018127	A-431	Microtubules
	HPA018127	U-2 OS	Microtubules
	HPA018127	U-251 MG	Cytosol

GENE INFORMATION
Gene name	NAV1 (HGNC Symbol)
Synonyms	DKFZp781D0314, FLJ12560, FLJ14203, KIAA1151, MGC14961, POMFIL3, steerin-1
Description	Neuron navigator 1 (HGNC Symbol)
Entrez gene summary	This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	201622885 - 201826969
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134369 (version 83.38)
Entrez gene	89796
UniProt	Q8NEY1 (UniProt - Evidence at protein level), M0R1G4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NEY1, NX_M0R1G4
Antibodypedia	NAV1 antibodies

PROTEIN BROWSER

NAV1-001	NAV1-002	NAV1-004	NAV1-006	NAV1-007	NAV1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAV1-001 ENSP00000356265 ENST00000367296	Q8NEY1 [Direct mapping] Neuron navigator 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001578 [microtubule bundle formation] GO:0001764 [neuron migration] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0015630 [microtubule cytoskeleton] Show all	1877 aa 202.5 kDa	No	0
NAV1-002 ENSP00000356264 ENST00000367295	Q8NEY1 [Direct mapping] Neuron navigator 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] Show all	1483 aa 160.8 kDa	No	0
NAV1-004 ENSP00000405437 ENST00000430015	H0Y6F6 [Direct mapping] Neuron navigator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		755 aa 79.8 kDa	No	0
NAV1-006 ENSP00000356271 ENST00000367302	A0A0A0MRJ3 [Direct mapping] Neuron navigator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] Show all	1830 aa 197.4 kDa	No	0
NAV1-007 ENSP00000389123 ENST00000438083	H7BZD9 [Direct mapping] Neuron navigator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		227 aa 24.6 kDa	No	0
NAV1-201 ENSP00000471857 ENST00000593583	M0R1G4 [Target identity:100%; Query identity:100%] Uncharacterized protein ENSP00000471857 A0A0A6YYD1 [Direct mapping] Neuron navigator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		241 aa 25.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.