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Few cases of squamous cell carcinoma of cervix, head-neck, skin and urothelial cancers displayed weak to moderate membranous and/or cytoplasmic staining. Remaining cancer tissues were negative.
Most cancer tissues showed weak to moderate nuclear and cytoplasmic staining. Several cases of squamous cell carcinomas exhibited moderate membranous and cytoplasmic positivity. Gliomas and lymphomas were negative.
GENE INFORMATION
Gene name
DSG3 (HGNC Symbol)
Synonyms
CDHF6
Description
Desmoglein 3 (HGNC Symbol)
Entrez gene summary
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq, Jul 2008]
