Fields »
ABOUT
HELP
BLOG
DSG3

GENERAL INFORMATION

Gene name

 DSG3

Gene description

 Desmoglein 3

Protein class

 Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (esophagus)
GTEx:Tissue enhanced (esophagus, vagina)
FANTOM5:Group enriched (esophagus, tonsil, cervix, uterine)

Protein evidence

 Evidence at protein level

Protein expression

 Selective membranous expression in squamous epithelia, most abundant in esophagus.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA046864 , HPA056863 , CAB069880
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, tonsil, cervix, uterine)

GENE INFORMATION

Gene name

 DSG3 (HGNC Symbol)

Synonyms

 CDHF6

Description

 Desmoglein 3 (HGNC Symbol)

Entrez gene summary

 Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 q12.1

Chromosome location (bp)

 31447795 - 31478702

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134757 (version 83.38)

Entrez gene

 1830

UniProt

 P32926 (UniProt - Evidence at protein level)

neXtProt

 NX_P32926

Antibodypedia

 DSG3 antibodies

PROTEIN BROWSER
DSG3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DSG3-001
ENSP00000257189
ENST00000257189
P32926 [Direct mapping]
Desmoglein-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030057 [desmosome]
GO:0070062 [extracellular exosome]
Show all
 999 aa
107.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.