Expression of KCNH3 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, voltage gated eag related subfamily H, member 3

Protein class

Predicted membrane proteins, Transporters, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA051088

GENE INFORMATION
Gene name	KCNH3 (HGNC Symbol)
Synonyms	BEC1, elk2, Kv12.2
Description	Potassium channel, voltage gated eag related subfamily H, member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Chromosome	12
Cytoband	q13.12
Chromosome location (bp)	49539157 - 49558308
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135519 (version 83.38)
Entrez gene	23416
UniProt	Q9ULD8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULD8
Antibodypedia	KCNH3 antibodies

PROTEIN BROWSER

KCNH3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNH3-001 ENSP00000257981 ENST00000257981	Q9ULD8 [Direct mapping] Potassium voltage-gated channel subfamily H member 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000155 [phosphorelay sensor kinase activity] GO:0000160 [phosphorelay signal transduction system] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0023014 [signal transduction by protein phosphorylation] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1083 aa 117.1 kDa	No	5