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KCNH3

GENERAL INFORMATION

Gene name

 KCNH3

Gene description

 Potassium channel, voltage gated eag related subfamily H, member 3

Protein class

 Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, fallopian tube, parathyroid gland)
GTEx:Group enriched (cerebral cortex, hippocampus, pituitary gland, caudate, cerebellum)
FANTOM5:Group enriched (hippocampus, caudate, brain, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA051088
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, fallopian tube, parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, hippocampus, pituitary gland, caudate, cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hippocampus, caudate, brain, pituitary gland)

GENE INFORMATION

Gene name

 KCNH3 (HGNC Symbol)

Synonyms

 BEC1, elk2, Kv12.2

Description

 Potassium channel, voltage gated eag related subfamily H, member 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 49539157 - 49558308

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135519 (version 83.38)

Entrez gene

 23416

UniProt

 Q9ULD8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULD8

Antibodypedia

 KCNH3 antibodies

PROTEIN BROWSER
KCNH3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNH3-001
ENSP00000257981
ENST00000257981
Q9ULD8 [Direct mapping]
Potassium voltage-gated channel subfamily H member 3
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Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0000155 [phosphorelay sensor kinase activity]
GO:0000160 [phosphorelay signal transduction system]
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 1083 aa
117.1 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.