Cell atlas - KCNH3 - The Human Protein Atlas

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KCNH3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleus

Human cell
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	KCNH3
Gene description	Potassium channel, voltage gated eag related subfamily H, member 3
Protein class	Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & mitochondria.
RNA cell category	Cell line enhanced (U-2 OS, A549, RPTEC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA051088
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2 OS, A549, RPTEC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & mitochondria.

Main location

Nucleus (approved), Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051088	A549	Nucleus
	HPA051088	A549	Mitochondria
	HPA051088	HaCaT	Nucleus
	HPA051088	HaCaT	Mitochondria
	HPA051088	U-2 OS	Nucleus
	HPA051088	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	KCNH3 (HGNC Symbol)
Synonyms	BEC1, elk2, Kv12.2
Description	Potassium channel, voltage gated eag related subfamily H, member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Chromosome	12
Cytoband	q13.12
Chromosome location (bp)	49539157 - 49558308
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135519 (version 83.38)
Entrez gene	23416
UniProt	Q9ULD8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULD8
Antibodypedia	KCNH3 antibodies

PROTEIN BROWSER

KCNH3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNH3-001 ENSP00000257981 ENST00000257981	Q9ULD8 [Direct mapping] Potassium voltage-gated channel subfamily H member 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000155 [phosphorelay sensor kinase activity] GO:0000160 [phosphorelay signal transduction system] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0023014 [signal transduction by protein phosphorylation] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1083 aa 117.1 kDa	No	5

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.