Cell atlas - GCC2 - The Human Protein Atlas

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GCC2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Nucleoplasm

Human cell
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GCC2
Gene description	GRIP and coiled-coil domain containing 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (validated)
Additional location	In addition localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA035849 , HPA035850
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to the nucleoplasm.

Main location

Golgi apparatus (validated)

Additional location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035849	A-431	Nucleoplasm
	HPA035849	A-431	Golgi apparatus
	HPA035849	U-2 OS	Nucleoplasm
	HPA035849	U-2 OS	Golgi apparatus
	HPA035849	U-251 MG	Nucleoplasm
	HPA035849	U-251 MG	Golgi apparatus
	HPA035850	SiHa	Nucleoplasm
	HPA035850	SiHa	Golgi apparatus
	HPA035850	U-2 OS	Golgi apparatus

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA035849	U-2 OS	Image	Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. GCC2 localizes to the Golgi apparatus, but not to the cis-Golgi compartment.

GENE INFORMATION
Gene name	GCC2 (HGNC Symbol)
Synonyms	GCC185, KIAA0336
Description	GRIP and coiled-coil domain containing 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Chromosome	2
Cytoband	q12.3
Chromosome location (bp)	108448561 - 108509415
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135968 (version 83.38)
Entrez gene	9648
UniProt	Q8IWJ2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWJ2
Antibodypedia	GCC2 antibodies

PROTEIN BROWSER

GCC2-003	GCC2-006	GCC2-008	GCC2-013	GCC2-014	GCC2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GCC2-003 ENSP00000386997 ENST00000409896	B8ZZW2 [Direct mapping] GRIP and coiled-coil domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] Show all	916 aa 107.1 kDa	No	0
GCC2-006 ENSP00000387350 ENST00000409821	B8ZZA5 [Direct mapping] GRIP and coiled-coil domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		247 aa 28.4 kDa	No	0
GCC2-008 ENSP00000475234 ENST00000462897	U3KPU4 [Direct mapping] GRIP and coiled-coil domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		146 aa 17.1 kDa	No	0
GCC2-013 ENSP00000475798 ENST00000492785	U3KQE0 [Direct mapping] GRIP and coiled-coil domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 14.6 kDa	No	0
GCC2-014 ENSP00000307939 ENST00000309863	Q8IWJ2 [Direct mapping] GRIP and coiled-coil domain-containing protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000042 [protein targeting to Golgi] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0006622 [protein targeting to lysosome] GO:0016020 [membrane] GO:0031023 [microtubule organizing center organization] GO:0034067 [protein localization to Golgi apparatus] GO:0034453 [microtubule anchoring] GO:0034499 [late endosome to Golgi transport] GO:0042147 [retrograde transport, endosome to Golgi] GO:0042802 [identical protein binding] GO:0070861 [regulation of protein exit from endoplasmic reticulum] GO:0071955 [recycling endosome to Golgi transport] GO:0090161 [Golgi ribbon formation] Show all	1684 aa 195.9 kDa	No	0
GCC2-201 ENSP00000482844 ENST00000614209	A0A087WZR8 [Direct mapping] GRIP and coiled-coil domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		683 aa 80 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.