Tissue expression of GCC2 - Summary - The Human Protein Atlas

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GCC2

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GCC2
Gene description	GRIP and coiled-coil domain containing 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA035849 , HPA035850
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	GCC2 (HGNC Symbol)
Synonyms	GCC185, KIAA0336
Description	GRIP and coiled-coil domain containing 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Chromosome	2
Cytoband	q12.3
Chromosome location (bp)	108448561 - 108509415
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135968 (version 83.38)
Entrez gene	9648
UniProt	Q8IWJ2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWJ2
Antibodypedia	GCC2 antibodies

PROTEIN BROWSER

GCC2-003	GCC2-006	GCC2-008	GCC2-013	GCC2-014	GCC2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GCC2-003 ENSP00000386997 ENST00000409896	B8ZZW2 [Direct mapping] GRIP and coiled-coil domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] Show all	916 aa 107.1 kDa	No	0
GCC2-006 ENSP00000387350 ENST00000409821	B8ZZA5 [Direct mapping] GRIP and coiled-coil domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		247 aa 28.4 kDa	No	0
GCC2-008 ENSP00000475234 ENST00000462897	U3KPU4 [Direct mapping] GRIP and coiled-coil domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		146 aa 17.1 kDa	No	0
GCC2-013 ENSP00000475798 ENST00000492785	U3KQE0 [Direct mapping] GRIP and coiled-coil domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 14.6 kDa	No	0
GCC2-014 ENSP00000307939 ENST00000309863	Q8IWJ2 [Direct mapping] GRIP and coiled-coil domain-containing protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000042 [protein targeting to Golgi] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0006622 [protein targeting to lysosome] GO:0016020 [membrane] GO:0031023 [microtubule organizing center organization] GO:0034067 [protein localization to Golgi apparatus] GO:0034453 [microtubule anchoring] GO:0034499 [late endosome to Golgi transport] GO:0042147 [retrograde transport, endosome to Golgi] GO:0042802 [identical protein binding] GO:0070861 [regulation of protein exit from endoplasmic reticulum] GO:0071955 [recycling endosome to Golgi transport] GO:0090161 [Golgi ribbon formation] Show all	1684 aa 195.9 kDa	No	0
GCC2-201 ENSP00000482844 ENST00000614209	A0A087WZR8 [Direct mapping] GRIP and coiled-coil domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		683 aa 80 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.