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IL36B

CANCER ATLAS

Gene description

 Interleukin 36, beta

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at transcript level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035664

GENE INFORMATION

Gene name

 IL36B (HGNC Symbol)

Synonyms

 FIL1, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2, MGC126880, MGC126882

Description

 Interleukin 36, beta (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q14.1

Chromosome location (bp)

 113022091 - 113052867

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000136696 (version 83.38)

Entrez gene

 27177

UniProt

 Q9NZH7 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9NZH7

Antibodypedia

 IL36B antibodies

PROTEIN BROWSER
IL36B-001
IL36B-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL36B-001
ENSP00000259213
ENST00000259213
Q9NZH7 [Direct mapping]
Interleukin-36 beta
Show all
Predicted intracellular proteins
Show all
GO:0001819 [positive regulation of cytokine production]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0045087 [innate immune response]
GO:0045582 [positive regulation of T cell differentiation]
Show all
 164 aa
18.5 kDa 		No 0
IL36B-002
ENSP00000328420
ENST00000327407
Q9NZH7 [Direct mapping]
Interleukin-36 beta
Show all
Predicted intracellular proteins
Show all
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0045087 [innate immune response]
Show all
 157 aa
17.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.