Tissue expression of IL36B - Summary - The Human Protein Atlas

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IL36B

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	IL36B
Gene description	Interleukin 36, beta
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (skin, tonsil, esophagus)
GTEx:	Group enriched (skin, esophagus)

Protein evidence

Evidence at transcript level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA035664
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skin, tonsil, esophagus)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (skin, esophagus)

GENE INFORMATION
Gene name	IL36B (HGNC Symbol)
Synonyms	FIL1, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2, MGC126880, MGC126882
Description	Interleukin 36, beta (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q14.1
Chromosome location (bp)	113022091 - 113052867
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000136696 (version 83.38)
Entrez gene	27177
UniProt	Q9NZH7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NZH7
Antibodypedia	IL36B antibodies

PROTEIN BROWSER

IL36B-001	IL36B-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL36B-001 ENSP00000259213 ENST00000259213	Q9NZH7 [Direct mapping] Interleukin-36 beta Show all	Predicted intracellular proteins Show all	GO:0001819 [positive regulation of cytokine production] GO:0002437 [inflammatory response to antigenic stimulus] GO:0005125 [cytokine activity] GO:0005149 [interleukin-1 receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006955 [immune response] GO:0019221 [cytokine-mediated signaling pathway] GO:0032755 [positive regulation of interleukin-6 production] GO:0045087 [innate immune response] GO:0045582 [positive regulation of T cell differentiation] Show all	164 aa 18.5 kDa	No	0
IL36B-002 ENSP00000328420 ENST00000327407	Q9NZH7 [Direct mapping] Interleukin-36 beta Show all	Predicted intracellular proteins Show all	GO:0002437 [inflammatory response to antigenic stimulus] GO:0005125 [cytokine activity] GO:0005149 [interleukin-1 receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006955 [immune response] GO:0019221 [cytokine-mediated signaling pathway] GO:0045087 [innate immune response] Show all	157 aa 17.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.