Expression of TET1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Tet methylcytosine dioxygenase 1

Protein class

Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA019032	CAB014886

GENE INFORMATION
Gene name	TET1 (HGNC Symbol)
Synonyms	bA119F7.1, CXXC6, KIAA1676, LCX
Description	Tet methylcytosine dioxygenase 1 (HGNC Symbol)
Entrez gene summary	DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015]
Chromosome	10
Cytoband	q21.3
Chromosome location (bp)	68560656 - 68694482
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138336 (version 83.38)
Entrez gene	80312
UniProt	Q8NFU7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFU7
Antibodypedia	TET1 antibodies

PROTEIN BROWSER

TET1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TET1-001 ENSP00000362748 ENST00000373644	Q8NFU7 [Direct mapping] Methylcytosine dioxygenase TET1 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001826 [inner cell mass cell differentiation] GO:0003677 [DNA binding] GO:0005506 [iron ion binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006493 [protein O-linked glycosylation] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0016568 [chromatin modification] GO:0019827 [stem cell population maintenance] GO:0035511 [oxidative DNA demethylation] GO:0040029 [regulation of gene expression, epigenetic] GO:0043566 [structure-specific DNA binding] GO:0044030 [regulation of DNA methylation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0070579 [methylcytosine dioxygenase activity] GO:0080111 [DNA demethylation] GO:0090310 [negative regulation of methylation-dependent chromatin silencing] GO:2000653 [regulation of genetic imprinting] Show all	2136 aa 235.3 kDa	No	0