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TET1

GENERAL INFORMATION

Gene name

 TET1

Gene description

 Tet methylcytosine dioxygenase 1

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (salivary gland)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA019032 , CAB014886
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (salivary gland)

GENE INFORMATION

Gene name

 TET1 (HGNC Symbol)

Synonyms

 bA119F7.1, CXXC6, KIAA1676, LCX

Description

 Tet methylcytosine dioxygenase 1 (HGNC Symbol)

Entrez gene summary

 DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015]

Chromosome

 10

Cytoband

 q21.3

Chromosome location (bp)

 68560656 - 68694482

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138336 (version 83.38)

Entrez gene

 80312

UniProt

 Q8NFU7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NFU7

Antibodypedia

 TET1 antibodies

PROTEIN BROWSER
TET1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TET1-001
ENSP00000362748
ENST00000373644
Q8NFU7 [Direct mapping]
Methylcytosine dioxygenase TET1
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001826 [inner cell mass cell differentiation]
GO:0003677 [DNA binding]
GO:0005506 [iron ion binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006493 [protein O-linked glycosylation]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016568 [chromatin modification]
GO:0019827 [stem cell population maintenance]
GO:0035511 [oxidative DNA demethylation]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043566 [structure-specific DNA binding]
GO:0044030 [regulation of DNA methylation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070579 [methylcytosine dioxygenase activity]
GO:0080111 [DNA demethylation]
GO:0090310 [negative regulation of methylation-dependent chromatin silencing]
GO:2000653 [regulation of genetic imprinting]
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 2136 aa
235.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.