Cell atlas - FBLN5 - The Human Protein Atlas

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FBLN5

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	FBLN5
Gene description	Fibulin 5
Protein class	Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Group enriched (BJ, BJ hTERT+, ASC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA000868 , CAB025843
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (BJ, BJ hTERT+, ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB025843	U-2 OS	Plasma membrane
	HPA000868	A-431	Cytosol
	HPA000868	U-2 OS	Plasma membrane
	HPA000868	U-2 OS	Cytosol

GENE INFORMATION
Gene name	FBLN5 (HGNC Symbol)
Synonyms	ARMD3, DANCE, EVEC, UP50
Description	Fibulin 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.12
Chromosome location (bp)	91869412 - 91947987
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140092 (version 83.38)
Entrez gene	10516
UniProt	Q9UBX5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBX5
Antibodypedia	FBLN5 antibodies

PROTEIN BROWSER

FBLN5-001	FBLN5-002	FBLN5-003	FBLN5-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBLN5-001 ENSP00000345008 ENST00000342058	Q9UBX5 [Direct mapping] Fibulin-5 A0A024R6G3 [Target identity:100%; Query identity:100%] Fibulin 5, isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005178 [integrin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007160 [cell-matrix adhesion] GO:0008022 [protein C-terminus binding] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0034394 [protein localization to cell surface] GO:0042803 [protein homodimerization activity] GO:0046903 [secretion] GO:0048251 [elastic fiber assembly] GO:0070062 [extracellular exosome] GO:0071953 [elastic fiber] GO:2000121 [regulation of removal of superoxide radicals] Show all	448 aa 50.2 kDa	Yes	0
FBLN5-002 ENSP00000267620 ENST00000267620	G3XA98 [Direct mapping] Fibulin 5, isoform CRA_a; Fibulin-5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	489 aa 54.1 kDa	Yes	0
FBLN5-003 ENSP00000451982 ENST00000556154	G3V4U0 [Direct mapping] Fibulin-5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	453 aa 50.9 kDa	Yes	0
FBLN5-005 ENSP00000451486 ENST00000554468	G3V3Y2 [Direct mapping] Fibulin-5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	91 aa 9.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.