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FBLN5

GENERAL INFORMATION

Gene name

 FBLN5

Gene description

 Fibulin 5

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Distinct positivity in extracellular matrix and tissue stroma.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 3 antibodies.
HPA000848 , HPA000868 , CAB025843
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FBLN5 (HGNC Symbol)

Synonyms

 ARMD3, DANCE, EVEC, UP50

Description

 Fibulin 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q32.12

Chromosome location (bp)

 91869412 - 91947987

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140092 (version 83.38)

Entrez gene

 10516

UniProt

 Q9UBX5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBX5

Antibodypedia

 FBLN5 antibodies

PROTEIN BROWSER
FBLN5-001
FBLN5-002
FBLN5-003
FBLN5-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBLN5-001
ENSP00000345008
ENST00000342058
Q9UBX5 [Direct mapping]
Fibulin-5
A0A024R6G3 [Target identity:100%; Query identity:100%]
Fibulin 5, isoform CRA_b
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0007160 [cell-matrix adhesion]
GO:0008022 [protein C-terminus binding]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0034394 [protein localization to cell surface]
GO:0042803 [protein homodimerization activity]
GO:0046903 [secretion]
GO:0048251 [elastic fiber assembly]
GO:0070062 [extracellular exosome]
GO:0071953 [elastic fiber]
GO:2000121 [regulation of removal of superoxide radicals]
Show all
 448 aa
50.2 kDa 		Yes 0
FBLN5-002
ENSP00000267620
ENST00000267620
G3XA98 [Direct mapping]
Fibulin 5, isoform CRA_a; Fibulin-5
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 489 aa
54.1 kDa 		Yes 0
FBLN5-003
ENSP00000451982
ENST00000556154
G3V4U0 [Direct mapping]
Fibulin-5
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 453 aa
50.9 kDa 		Yes 0
FBLN5-005
ENSP00000451486
ENST00000554468
G3V3Y2 [Direct mapping]
Fibulin-5
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
Show all
 91 aa
9.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.