Cell atlas - UNC45A - The Human Protein Atlas

GENERAL INFORMATION
Gene name	UNC45A
Gene description	Unc-45 myosin chaperone A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (supported)
Additional location	In addition localized to the Cytosol (supported)
Mouse	Localized to the Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA039228
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles. In addition localized to the cytosol.

Main location

Nuclear speckles (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA039228	HEK 293	Golgi apparatus
HPA039228	HEK 293	Cytosol
HPA039228	MCF7	Nuclear speckles
HPA039228	MCF7	Cytosol
HPA039228	U-2 OS	Cytosol

MOUSE CELLS

Main location

Cytosol

Mouse gene

ENSMUSG00000030533 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA039228	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	UNC45A (HGNC Symbol)
Synonyms	GC-UNC45, SMAP-1
Description	Unc-45 myosin chaperone A (HGNC Symbol)
Entrez gene summary	UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008]
Chromosome	15
Cytoband	q26.1
Chromosome location (bp)	90930180 - 90954093
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140553 (version 83.38)
Entrez gene	55898
UniProt	Q9H3U1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H3U1
Antibodypedia	UNC45A antibodies

PROTEIN BROWSER

UNC45A-001	UNC45A-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UNC45A-001 ENSP00000377816 ENST00000394275	Q9H3U1 [Direct mapping] Protein unc-45 homolog A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007517 [muscle organ development] GO:0030154 [cell differentiation] GO:0048471 [perinuclear region of cytoplasm] Show all	929 aa 101.7 kDa	No	0
UNC45A-002 ENSP00000407487 ENST00000418476	Q9H3U1 [Direct mapping] Protein unc-45 homolog A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007517 [muscle organ development] GO:0030154 [cell differentiation] GO:0048471 [perinuclear region of cytoplasm] GO:0051879 [Hsp90 protein binding] GO:0061077 [chaperone-mediated protein folding] Show all	944 aa 103.1 kDa	No	0