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UNC45A

GENERAL INFORMATION

Gene name

 UNC45A

Gene description

 Unc-45 myosin chaperone A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039228
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UNC45A (HGNC Symbol)

Synonyms

 GC-UNC45, SMAP-1

Description

 Unc-45 myosin chaperone A (HGNC Symbol)

Entrez gene summary

 UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008]

Chromosome

 15

Cytoband

 q26.1

Chromosome location (bp)

 90930180 - 90954093

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140553 (version 83.38)

Entrez gene

 55898

UniProt

 Q9H3U1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H3U1

Antibodypedia

 UNC45A antibodies

PROTEIN BROWSER
UNC45A-001
UNC45A-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UNC45A-001
ENSP00000377816
ENST00000394275
Q9H3U1 [Direct mapping]
Protein unc-45 homolog A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0007517 [muscle organ development]
GO:0030154 [cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
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 929 aa
101.7 kDa 		No 0
UNC45A-002
ENSP00000407487
ENST00000418476
Q9H3U1 [Direct mapping]
Protein unc-45 homolog A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0007517 [muscle organ development]
GO:0030154 [cell differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051879 [Hsp90 protein binding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 944 aa
103.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.