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Hepatocellular carcinomas displayed moderate to strong cytoplasmic staining. SEveral malignant gliomas, renal and pancreatic cancers along with a few colorectal and ovarian cancers showed moderate positivity. Remaining malignant cells were generally negative.
Malignant cells were generally negative. Hepatocellular carcinomas exhibited strong cytoplasmic staining
GENE INFORMATION
Gene name
ASGR1 (HGNC Symbol)
Synonyms
CLEC4H1
Description
Asialoglycoprotein receptor 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
