Cell atlas - ASGR1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ASGR1

premium

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Vesicles

Human cell
	Plasma Membrane
	Vesicles

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	ASGR1
Gene description	Asialoglycoprotein receptor 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the cell junctions.
RNA cell category	Cell line enriched (Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)
Additional location	In addition localized to the Cell Junctions (approved)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA011954 , HPA012852
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the cell junctions.

Main location

Vesicles (supported)

Additional location

Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA011954	Hep G2	Vesicles
	HPA012852	CACO-2	No staining
	HPA012852	Hep G2	Vesicles
	HPA012852	Hep G2	Cell Junctions
	HPA012852	U-2 OS	No staining

GENE INFORMATION
Gene name	ASGR1 (HGNC Symbol)
Synonyms	CLEC4H1
Description	Asialoglycoprotein receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7173431 - 7179564
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141505 (version 83.38)
Entrez gene	432
UniProt	P07306 (UniProt - Evidence at protein level)
neXtProt	NX_P07306
Antibodypedia	ASGR1 antibodies

PROTEIN BROWSER

ASGR1-001	ASGR1-002	ASGR1-007	ASGR1-008	ASGR1-009	ASGR1-010	ASGR1-011	ASGR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASGR1-001 ENSP00000269299 ENST00000269299	P07306 [Direct mapping] Asialoglycoprotein receptor 1 Q6FGQ5 [Target identity:100%; Query identity:100%] ASGR1 protein; Asialoglycoprotein receptor 1; Asialoglycoprotein receptor 1, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004873 [asialoglycoprotein receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0030246 [carbohydrate binding] GO:0031668 [cellular response to extracellular stimulus] GO:0042803 [protein homodimerization activity] GO:0046872 [metal ion binding] Show all	291 aa 33.2 kDa	No	0
ASGR1-002 ENSP00000459169 ENST00000574388	P07306 [Direct mapping] Asialoglycoprotein receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005887 [integral component of plasma membrane] GO:0030246 [carbohydrate binding] GO:0046872 [metal ion binding] Show all	252 aa 29.1 kDa	No	0
ASGR1-007 ENSP00000467511 ENST00000574330	K7EPS5 [Direct mapping] Asialoglycoprotein receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		162 aa 18.4 kDa	No	0
ASGR1-008 ENSP00000370307 ENST00000380920	J3QSZ2 [Direct mapping] Asialoglycoprotein receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		190 aa 22 kDa	No	0
ASGR1-009 ENSP00000458530 ENST00000572879	I3L129 [Direct mapping] Asialoglycoprotein receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 10.9 kDa	No	0
ASGR1-010 ENSP00000458803 ENST00000570576	I3L1F8 [Direct mapping] Asialoglycoprotein receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		30 aa 3.5 kDa	No	0
ASGR1-011 ENSP00000459896 ENST00000573083	I3L2S9 [Direct mapping] Asialoglycoprotein receptor 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	117 aa 13 kDa	No	0
ASGR1-201 ENSP00000481182 ENST00000619926	P07306 [Direct mapping] Asialoglycoprotein receptor 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005887 [integral component of plasma membrane] GO:0030246 [carbohydrate binding] GO:0046872 [metal ion binding] Show all	252 aa 29.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.